Record in detail

General Info

lamp_id:L01A000618
Name:AUR25_LITRA
FullName:Aurein-2.5
Source:Litoria raniformis
Mass:1650 Da
Sequence Length:16 aa
Isoelectric Point:9.53
Activity:Antibacterial, ,Anticancer,Anticancer
Sequence
GLFDIVKKVVGAFGSL
Function:Has antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, S.aureus, and S.epidermidis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.

Cross-Linking

Cross-linking
1 Database:APD 18
2 Database:CAMP CAMPSQ578
3 Database:DBAASP 1253
4 Database:dbAMP dbAMP_03291
5 Database:DRAMP DRAMP01612
6 Database:SATPdb satpdb20730
7 Database:Uniprot P69018

Top similar AMPs

Top similar AMPs on LAMP
1. L12A06192| From 50 To 65 E-value: 0.0007 Score: 33.9
GLFDIVKKVVGAFGSL
2. L01A000618 From 1 To 16 E-value: 0.002 Score: 32.3
GLFDIVKKVVGAFGSL
3. L12A06194| From 50 To 65 E-value: 0.003 Score: 32
GLFDIVKKVVGAIGSL
4. L12A06193| From 50 To 65 E-value: 0.003 Score: 31.6
GLFDIVKKVVGALGSL
5. L13A022551 From 1 To 15 E-value: 0.006 Score: 30.8
GLFDIVKKVVGAFGS

Structure

Domains
1 Name:Aurein_antimicrobial_peptide Interpro Link:IPR013157

Structures

Activity

Antibacterial Activities
1 Target: B.cereus MIC: 50 μg/ml (30.303 μM)
2 Target: L.lactis MIC: 12 μg/ml (7.27273 μM)
3 Target: L.innocua MIC: 50 μg/ml (30.303 μM)
4 Target: M.luteus MIC: 100 μg/ml (60.6061 μM)
5 Target: S.aureus MIC: 50 μg/ml (30.303 μM)
6 Target: S.epidermidis MIC: 100 μg/ml (60.6061 μM)

Toxicity

Toxicity

Reference

Reference
[1] Carver J.A.,Olver I.N.,Bowie J.H.,Wegener K.L.,Rozek T.,
Title:The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
Journal:Eur. J. Biochem., 2000, 267, 5330-5341 [MEDLINE:20408845]

Comments

Comments