Record in detail

General Info

lamp_id:L01A000622
Name:AUR32_LITRA
FullName:Aurein-3.2
Source:Litoria raniformis
Mass:1769.1 Da
Sequence Length:17 aa
Isoelectric Point:9.53
Activity:Antibacterial, ,Anticancer,Anticancer
Sequence
GLFDIVKKIAGHIASSI
Function:Has antimicrobial activity against L.lactis, L.innocua, M.luteus, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.

Cross-Linking

Cross-linking
1 Database:APD 21
2 Database:CAMP CAMPSQ582
3 Database:DBAASP 1261
4 Database:dbAMP dbAMP_03287
5 Database:DRAMP DRAMP01617
6 Database:SATPdb satpdb13137
7 Database:Uniprot P69022

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000622 From 1 To 17 E-value: 0.0004 Score: 34.7
GLFDIVKKIAGHIASSI
2. L12A06191| From 50 To 66 E-value: 0.0007 Score: 33.9
GLFDIVKKIAGHIAGSI
3. L01A000255 From 1 To 17 E-value: 0.001 Score: 33.1
GLFDIVKKIAGHIVSSI
4. L01A000620 From 1 To 17 E-value: 0.001 Score: 32.7
GLFDIVKKIAGHIAGSI
5. L13A024119 From 1 To 14 E-value: 0.011 Score: 30
GLFDIVKKIAGHIA

Structure

Domains
1 Name:Aurein_antimicrobial_peptide Interpro Link:IPR013157

Structures

Activity

Antibacterial Activities
1 Target: L.lactis MIC: 6 μg/ml (3.39156 μM)
2 Target: L.innocua MIC: 100 μg/ml (56.5259 μM)
3 Target: M.luteus MIC: 100 μg/ml (56.5259 μM)
4 Target: S.aureus MIC: 50 μg/ml (28.263 μM)
5 Target: S.epidermidis MIC: 50 μg/ml (28.263 μM)
6 Target: S.uberis MIC: 50 μg/ml (28.263 μM)
7 Target: S. aureus MIC: 50.0832 μg/ml (28.31 μM)

Toxicity

Toxicity

Reference

Reference
[1] Carver J.A.,Olver I.N.,Bowie J.H.,Wegener K.L.,Rozek T.,
Title:The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
Journal:Eur. J. Biochem., 2000, 267, 5330-5341 [MEDLINE:20408845]

Comments

Comments