Record in detail


General Info

  • lamp_id:L01A000628
  • Name:PHYL2_PHYHY
  • FullName:Phylloseptin-2
  • Source:Phyllomedusa hypochondrialis
  • Mass:2016.3 Da
  • Sequence Length:19 aa
  • Isoelectric Point:9.69
  • Activity:Antibacterial
  • Sequence
        FLSLIPHAINAVSAIAKHN
  • Function:Has antimicrobial activity. No hemolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06189|    From 47 To 64 E-value: 0.00001 Score: 40
        FLSLIPHAINAVSAIAKH
  • 2. L12A06190|    From 47 To 64 E-value: 0.00003 Score: 38.9
        FLSLIPHAINAVSAIAKH
  • 3. L12A02203|    From 1 To 19 E-value: 0.00003 Score: 38.5
        FLSLIPHAINAVSAIAKHN
  • 4. L01A000628    From 1 To 19 E-value: 0.00003 Score: 38.5
        FLSLIPHAINAVSAIAKHN
  • 5. L01A000630    From 1 To 19 E-value: 0.0001 Score: 37
        FLSLIPHAINAVSAIAKHS

Structure

  •   Domains
  •   1  Name:Brevinin    Interpro Link:IPR004275
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  S.aureus  MIC:  15.93 μg/ml  (7.90061 μM)  
  •   2  Target:  E.faecalis  MIC:  8.07 μg/ml  (4.00238 μM)  
  •   3  Target:  E.coli  MIC:  15.93 μg/ml  (7.90061 μM)  
  •   4  Target:  P.aeruginosa  MIC:  8.07 μg/ml  (4.00238 μM)  
  •   5  Target:  E. coli  MIC:  15.9288 μg/ml  (7.9 μM)  
  •   6  Target:  S. aureus  MIC:  15.9288 μg/ml  (7.9 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Brand G.D.,Prates M.V.,Rodrigues M.I.S.,Silva L.P.,Leite J.R.S.A.,
  •   Title:Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.
  •   Journal:Peptides, 2005, 26, 565-573  [PubMed:15752569]
  •   [2]  Shaw C.,Walker B.,Gagliardo R.,Zhou M.,Chen T.,
  •   Title:Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis.
  •   Journal:Peptides, 2006, 27, 2129-2136  [PubMed:16713656]
  •   [3]  Almeida F.C.,Cesar A.,Prates M.V.,Moraes C.M.,Resende J.M.,
  •   Title:Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations.
  •   Journal:Peptides, 2008, 29, 1633-1644  [PubMed:18656510]

Comments

  •   Comments

    •     No comments found on LAMP database



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