Record in detail
General Info
- lamp_id:L01A000633
- Name:RNAM_PLESA
- FullName:Antimicrobial ribonuclease
- Source:Pleurotus sajor-caju
- Mass:1016 Da
- Sequence Length:10 aa
- Isoelectric Point:6.51
- Activity:Antibacterial, Antifungal
- Sequence
DNGEAGRAAR - Function:Has ribonuclease activity towards yeast tRNA and polyuracil and weak ribonuclease activity towards other polyhomoribonucleotides. Has weak deoxyribonuclease activity. Displays antimitogenic activity towards murine splenocytes and antiproliferative activity towards HepG2 hepatoma cells and L1210 leukemia cells. Has antibacterial activity against Gram-negative bacteria P.aeruginosa and P.fluorescens, and the Gram-positive bacterium S.aureus. No antibacterial activity against the Gram-positive bacteria B.subtilis, B.cereus, B.megaterium, M.luteus and M.phei, or the Gram-negative bacteria E.coli and E.aerogenes. Has antifungal activity against F.oxysporum and M.oxysporum.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ593
- 2 Database:DBAASP 1655
- 3 Database:dbAMP dbAMP_01146
- 4 Database:DRAMP DRAMP03473
- 5 Database:SATPdb satpdb15043
- 6 Database:Uniprot P84528
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000633 From 1 To 10 E-value: 1.4 Score: 21.9
DNGEAGRAAR
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
- 1 Target: Fusarium oxysporum IC50: 96.52 μg/ml (95 μM)
- 2 Target: Mycosphaerella arachidicola IC50: 73.15 μg/ml (71.998 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Ng T.B.,Ngai P.H.K.,
- Title:A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju.
- Journal:Peptides, 2004, 25, 11-17 [PubMed:15003351]
Comments
- Comments
No comments found on LAMP database