Record in detail

lamp_id:L01A000638
Name:BR1E_RANES
FullName:Brevinin-1E
Source:Rana esculenta
Mass:2678.3 Da
Sequence Length:24 aa
Isoelectric Point:10.51
Activity:Antibacterial
Sequence
FLPLLAGLAANFLPKIFCKITRKC
Function:Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity.

Top similar AMPs on LAMP
1. L03A000118 From 48 To 71 E-value: 0.000000004 Score: 51.6
FLPLLAGLAANFLPKIFCKITRKC
2. L12A07327| From 48 To 71 E-value: 0.00000002 Score: 49.7
FLPLLAGLAANFLPKIFCKITKKC
3. L12A07014| From 47 To 70 E-value: 0.00000002 Score: 49.3
FLPLLAGLAANFLPKIFCKITKKC
4. L01A000638 From 1 To 24 E-value: 0.00000002 Score: 49.3
FLPLLAGLAANFLPKIFCKITRKC
5. L13A018943 From 1 To 24 E-value: 0.00000003 Score: 48.9
FLPMLAGLAANFLPKIFCKITRKC

Antibacterial Activities
1 Target: E.coliD21 MIC: 4.82 μg/ml (1.79965 μM)
2 Target: B.megaterium Bm11 MIC: 1.07 μg/ml (0.399507 μM)
3 Target: S.aureus Cowan1 MIC: 1.61 μg/ml (0.601128 μM)
4 Target: P.aeruginosa ATCC15692 MIC: 81.96 μg/ml (30.6015 μM)
5 Target: C. albicans MIC: 12.59 μg/ml (4.70074 μM)
6 Target: S. cerevisiae MIC: 10.18 μg/ml (3.80092 μM)
7 Target: E. coli MIC: 6.24044 μg/ml (2.33 μM)
8 Target: S. aureus MIC: 6.24044 μg/ml (2.33 μM)

Reference
[1] Bossa F.,Barra D.,Mignogna G.,Simmaco M.,
Title:Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta.
Journal:FEBS Lett., 1993, 324, 159-161 [MEDLINE:93285327]
[2] Bossa F.,Barra D.,Mignogna G.,Simmaco M.,
Title:Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
Journal:J. Biol. Chem., 1994, 269, 11956-11961 [MEDLINE:94216303]