Record in detail


General Info

  • lamp_id:L01A000643
  • Name:BR2EF_RANES
  • FullName:Brevinin-2Ef
  • Source:Rana esculenta
  • Mass:3367 Da
  • Sequence Length:33 aa
  • Isoelectric Point:10.23
  • Activity:Antibacterial
  • Sequence
        GIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC
  • Function:Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000122    From 42 To 74 E-value: 0.0000000000001 Score: 66.6
        GIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC
  • 2. L01A000643    From 1 To 33 E-value: 0.0000000000003 Score: 65.5
        GIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC
  • 3. L01A000640    From 1 To 33 E-value: 0.000000000004 Score: 62
        GILDTLKNLAKTAGKGALQGLVKMASCKLSGQC
  • 4. L01A003319    From 1 To 33 E-value: 0.00000000001 Score: 60.1
        GIMDTLKNLAKTAGKGALQSLLNHASCKLSGQC
  • 5. L01A000488    From 1 To 33 E-value: 0.00000000002 Score: 59.3
        GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC

Structure

  •   Domains
  •   1  Name:Antimicrobial_frog_2    Interpro Link:IPR012521
  •   2  Name:Brevinin    Interpro Link:IPR004275
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E.coli D21  MIC:  1.68 μg/ml  (0.49896 μM)  
  •   2  Target:  B.megaterium BmII  MIC:  0.67 μg/ml  (0.19899 μM)  
  •   3  Target:  S.aureus Cowan 1  MIC:  6.73 μg/ml  (1.99881 μM)  
  •   4  Target:  P.aeruginosa ATCC15692  MIC:  101.01 μg/ml  (30 μM)  

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Bossa F.,Barra D.,Mignogna G.,Simmaco M.,
  •   Title:Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
  •   Journal:J. Biol. Chem., 1994, 269, 11956-11961  [MEDLINE:94216303]

Comments

  •   Comments

  •     No comments found on LAMP database



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