Record in detail


General Info

  • lamp_id:L01A000645
  • Name:ES1A_RANES
  • FullName:Esculentin-1A
  • Source:Rana esculenta
  • Mass:4802.8 Da
  • Sequence Length:46 aa
  • Isoelectric Point:10.34
  • Activity:Antibacterial
  • Sequence
        GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
  • Function:Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A04132|    From 25 To 70 E-value: 3e-20 Score: 89
        GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
  • 2. L12A04123|    From 25 To 70 E-value: 3e-20 Score: 88.6
        GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
  • 3. L03A000115    From 39 To 84 E-value: 4e-20 Score: 88.2
        GIFSKLAGKKLKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
  • 4. L12A04130|    From 25 To 70 E-value: 4e-20 Score: 88.2
        GIFSKLAGKKIKNLLISGLKNIGKEVGMDVVRTGIDIAGCKIKGEC
  • 5. L12A04302|    From 25 To 70 E-value: 5e-20 Score: 88.2
        GIFSKLAGKKIKNLLISGLKNIGKEVGMDVVRTGIDIAGCKIKGEC

Structure

  •   Domains
  •   1  Name:Antimicrobial_frog_2    Interpro Link:IPR012521
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  13.4478 μg/ml  (2.8 μM)  
  •   2  Target:  S. aureus  MIC:  20.652 μg/ml  (4.3 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Bossa F.,Barra D.,Mignogna G.,Simmaco M.,
  •   Title:Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
  •   Journal:J. Biol. Chem., 1994, 269, 11956-11961  [MEDLINE:94216303]

Comments

  •   Comments

    •     No comments found on LAMP database



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