Record in detail


General Info

  • lamp_id:L01A000648
  • Name:MYR1_MYRPI
  • FullName:Pilosulin-1
  • Source:Myrmecia pilosula
  • Mass:2108.6 Da
  • Sequence Length:20 aa
  • Isoelectric Point:12.81
  • Activity:Antibacterial, Antifungal
  • Sequence
        GLGSVFGRLARILGRVIPKV
  • Function:Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. The synthesized peptide 57-76 shows a potent and broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, and also against the fungus C.albicans. Adopts an alpha-helical structure.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L02A000535    From 1 To 20 E-value: 0.000005 Score: 41.2
        GLGSVFGRLARILGRVIPKV
  • 2. L13A023974    From 1 To 20 E-value: 0.000008 Score: 40.8
        GLGSVFGRLARILGRVIPKV
  • 3. L01A000648    From 1 To 20 E-value: 0.00002 Score: 39.3
        GLGSVFGRLARILGRVIPKV
  • 4. L13A020370    From 1 To 19 E-value: 0.001 Score: 33.1
        GLGSVFGRLARI-GRVIPKV
  • 5. L01A000302    From 1 To 20 E-value: 0.011 Score: 30
        GLLSKFGRLARKLARVIPKV

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S. simulans 22  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   2  Target:  M. luteus  MIC:  1.05 μg/ml  (0.497961 μM)  
  •   3  Target:  Enterococcus spp. I-11305b  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   4  Target:  Enterococcus spp. I-11054  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   5  Target:  S. haemolyticus I-10925  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   6  Target:  S. epidermidis LT1324  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   7  Target:  S. aureus 5185  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   8  Target:  S. aureus methicillin-sensitive I-11574  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   9  Target:  S. aureus MRSA LT1338  MIC:  6.33 μg/ml  (3.00199 μM)  
  •   10  Target:  S. aureus MRSA LT1334  MIC:  3.16 μg/ml  (1.49862 μM)  
  •   11  Target:  C. freundii I-11090  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   12  Target:  K. pneumoniae I-10910  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   13  Target:  E. coli I-11276b  MIC:  8.43 μg/ml  (3.99791 μM)  
  •   14  Target:  E. coli O-19592  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   15  Target:  S. maltophila O-16451  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   16  Target:  S. maltophila I-10717  MIC:  4.22 μg/ml  (2.00133 μM)  
  •   17  Target:  P. aeruginosa 4991  MIC:  8.43 μg/ml  (3.99791 μM)  
  •   18  Target:  P. aeruginosa I-10968  MIC:  8.43 μg/ml  (3.99791 μM)  
  •   19  Target:  C. albicans I-11301  MIC:  8.43 μg/ml  (3.99791 μM)  
  •   20  Target:  C. albicans I-11134  MIC:  8.43 μg/ml  (3.99791 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Sutherland S.K.,Baldo B.A.,Donovan G.R.,
  •   Title:Molecular cloning and characterization of a major allergen (Myr p I) from the venom of the Australian jumper ant, Myrmecia pilosula.
  •   Journal:Biochim. Biophys. Acta, 1993, 1171, 272-280  [MEDLINE:93144338]
  •   [2]  Alewood P.F.,Alewood D.,Baldo B.A.,Street M.D.,Donovan G.R.,
  •   Title:Identification of an IgE-binding determinant of the major allergen Myr p I from the venom of the Australian jumper ant Myrmecia pilosula.
  •   Journal:Biochim. Biophys. Acta, 1994, 1204, 48-52  [MEDLINE:94137760]
  •   [3]  Alewood D.,Smith A.I.,Tetaz T.,Street M.D.,Donovan G.R.,
  •   Title:Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products.
  •   Journal:Biochem. Mol. Biol. Int., 1996, 39, 877-885  [PubMed:8866004]
  •   [4]  Baldo B.A.,Donovan G.R.,Street M.D.,
  •   Title:Molecular cloning and characterization of the major allergen Myr p II from the venom of the jumper ant Myrmecia pilosula: Myr p I and Myr p II share a common protein leader sequence.
  •   Journal:Biochim. Biophys. Acta, 1996, 1305, 87-97  [MEDLINE:96180991]
  •   [5]  Alewood P.F.,Alewood D.,Donovan G.R.,King M.A.,Wu Q.-X.,
  •   Title:Cytotoxicity of pilosulin 1, a peptide from the venom of the jumper ant Myrmecia pilosula.
  •   Journal:Biochim. Biophys. Acta, 1998, 1425, 74-80  [MEDLINE:99030001]
  •   [6]  Baldo B.A.,Donovan G.R.,Wu Q.-X.,King M.A.,
  •   Title:Flow cytometric analysis of cell killing by the jumper ant venom peptide pilosulin 1.
  •   Journal:Cytometry, 1998, 32, 268-273  [PubMed:9701394]
  •   [7]  Brown S.G.A.,Wiese M.D.,Davies N.W.,
  •   Title:Characterisation of major peptides in "jack jumper" ant venom by mass spectrometry.
  •   Journal:Toxicon, 2004, 43, 173-183  [PubMed:15019477]
  •   [8]  Tossi A.,Sahl H.-G.,Antcheva N.,Pag U.,Zelezetsky I.,
  •   Title:Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.
  •   Journal:Arch. Biochem. Biophys., 2005, 434, 358-364  [PubMed:15639237]

Comments

  •   Comments

    •     No comments found on LAMP database



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