Record in detail
General Info
- lamp_id:L01A000649
- Name:PYLAA_XENLA
- FullName:PYLa/PGLa A
- Source:Xenopus laevis
- Mass:1969.4 Da
- Sequence Length:21 aa
- Isoelectric Point:11.28
- Activity:Antimicrobial
- Sequence
GMASKAGAIAGKIAKVALKAL - Function:PGLa and PGLa-H display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria. PGLa also displays antifungal activity against C.albicans ATCC 14053. PGLa-H shows moderate antibacterial activity against the multidrug-resistant methicillin-resistant S. aureus (MRSA) but exhibits very little hemolytic activity.
Cross-Linking
- Cross-linking
- 1 Database:APD 210
- 2 Database:CAMP CAMPSQ609
- 3 Database:DBAASP 37
- 4 Database:dbAMP dbAMP_03865
- 5 Database:DRAMP DRAMP02272
- 6 Database:SATPdb satpdb16018
- 7 Database:Uniprot Q99134
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000314 From 39 To 59 E-value: 0.00004 Score: 38.5
GMASKAGAIAGKIAKVALKAL - 2. L13A024362 From 4 To 24 E-value: 0.00007 Score: 37.4
GMASKAGAIAGKIAKVALKAL - 3. L01A000649 From 1 To 21 E-value: 0.00009 Score: 37
GMASKAGAIAGKIAKVALKAL - 4. L13A014881 From 1 To 21 E-value: 0.0001 Score: 37
GMASKAGAIAGKIAKVALKAL - 5. L11A008259 From 1 To 21 E-value: 0.0001 Score: 37
GMASKAGAIAGKIAKVALKAL
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
- 1 Target: Escherichia coli 25922 MIC: 62 μg/ml (31.4817 μM)
- 2 Target: Klebsiella pneumoniae 13883 MIC: 250 μg/ml (126.942 μM)
- 3 Target: Pseudomonas aeruginosa 27853 MIC: 250 μg/ml (126.942 μM)
- 4 Target: Staphylococcus aureus 29213 MIC: 125 μg/ml (63.4711 μM)
- 5 Target: Strepococcus faecalis MIC: 500 μg/ml (253.884 μM)
- 6 Target: Candida albicans 14053 MIC: 250 μg/ml (126.942 μM)
- 7 Target: E. coli MIC: 25.0114 μg/ml (12.7 μM)
- 8 Target: S. aureus MIC: 6.243 μg/ml (3.17 μM)
Toxicity
- Toxicity
Reference
- Reference
- [1] Kreil G.,Richter K.,Hoffmann W.,
- Title:A novel peptide designated PYLa and its precursor as predicted from cloned mRNA of Xenopus laevis skin.
- Journal:EMBO J., 1983, 2, 711-714 [MEDLINE:84057748]
- [2] Williams D.H.,Gibson B.W.,Poulter L.,Giovannini M.G.,
- Title:Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones.
- Journal:Biochem. J., 1987, 243, 113-120 [PubMed:3606567]
- [3] Sures I.,Kreil G.,Kuchler K.,
- Title:The genes for the frog skin peptides GLa, xenopsin, levitide and caerulein contain a homologous export exon encoding a signal sequence and part of an amphiphilic peptide.
- Journal:Eur. J. Biochem., 1989, 179, 281-285 [MEDLINE:89137103]
- [4] Turner K.,Tomassini N.,Brasseur M.M.,Bevins C.L.,Moore K.S.,
- Title:Antimicrobial peptides in the stomach of Xenopus laevis.
- Journal:J. Biol. Chem., 1991, 266, 19851-19857 [MEDLINE:92011794]
- [5] Liu L.,Xu J.,Pan P.,Li J.,Hou F.,
- Title:Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis.
- Journal:Int. J. Antimicrob. Agents, 2011, 38, 510-515 [PubMed:22014884]
Comments
- Comments
No comments found on LAMP database