Record in detail


General Info

  • lamp_id:L01A000650
  • Name:RLXN_LITCT
  • FullName:Ranalexin
  • Source:Lithobates catesbeiana
  • Mass:2105.7 Da
  • Sequence Length:20 aa
  • Isoelectric Point:9.67
  • Activity:Antibacterial, Antifungal
  • Sequence
        FLGGLIKIVPAMICAVTKKC
  • Function:Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000117    From 47 To 66 E-value: 0.000001 Score: 43.5
        FLGGLIKIVPAMICAVTKKC
  • 2. L11A009230    From 1 To 20 E-value: 0.000002 Score: 42.7
        FLGGLIKIVPAMICAVTKKC
  • 3. L01A000650    From 1 To 20 E-value: 0.000005 Score: 41.2
        FLGGLIKIVPAMICAVTKKC
  • 4. L12A01908|    From 1 To 20 E-value: 0.00002 Score: 39.3
        FLGGLIKIVPAMICAVRKKC
  • 5. L01A000655    From 1 To 19 E-value: 0.00002 Score: 38.9
        FLGGLIKIVPAMICAVTKK

Structure

  •   Domains
  •   1  Name:Antimicrobial_frog_1    Interpro Link:IPR012520
  •   2  Name:Brevinin    Interpro Link:IPR004275
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S.aureus  MIC:  4 μg/ml  (1.89961 μM)  
  •   2  Target:  E.coli  MIC:  32 μg/ml  (15.1968 μM)  
  •   3  Target:  P.aeruginosa  MIC:  128 μg/ml  (60.7874 μM)  
  •   4  Target:  E. coli  MIC:  32.0066 μg/ml  (15.2 μM)  
  •   5  Target:  S. aureus  MIC:  4.00083 μg/ml  (1.9 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Zasloff M.,Maloy W.L.,Durell S.,Clark D.P.,
  •   Title:Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.
  •   Journal:J. Biol. Chem., 1994, 269, 10849-10855  [MEDLINE:94193792]
  •   [2]  Grassy G.,Chiche L.,Roch P.,Chavanieu A.,Vignal E.,
  •   Title:Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles.
  •   Journal:Eur. J. Biochem., 1998, 253, 221-228  [MEDLINE:98237592]

Comments

  •   Comments

    •     No comments found on LAMP database



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