Record in detail
General Info
- lamp_id:L01A000653
- Name:RLXN_LITCT
- FullName:Ranalexin
- Source:Lithobates catesbeiana
- Mass:1845.4 Da
- Sequence Length:18 aa
- Isoelectric Point:9.67
- Activity:Antibacterial
- Sequence
GGLIKIVPAMICAVTKKC - Function:Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ613
- 2 Database:DBAASP 1316
- 3 Database:dbAMP dbAMP_02732
- 4 Database:DRAMP DRAMP03947
- 5 Database:SATPdb satpdb26719
- 6 Database:Uniprot P39084
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000117 From 49 To 66 E-value: 0.00001 Score: 40
GGLIKIVPAMICAVTKKC - 2. L11A009230 From 3 To 20 E-value: 0.00003 Score: 38.5
GGLIKIVPAMICAVTKKC - 3. L01A000650 From 3 To 20 E-value: 0.00007 Score: 37.4
GGLIKIVPAMICAVTKKC - 4. L01A000654 From 2 To 19 E-value: 0.00008 Score: 37.4
GGLIKIVPAMICAVTKKC - 5. L01A000653 From 1 To 18 E-value: 0.00008 Score: 37
GGLIKIVPAMICAVTKKC
Activity
- Antibacterial Activities
- 1 Target: S.aureus MIC: 256 μg/ml (138.723 μM)
- 2 Target: E.coli MIC: 256 μg/ml (138.723 μM)
- 3 Target: P.aeruginosa MIC: 256 μg/ml (138.723 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Zasloff M.,Maloy W.L.,Durell S.,Clark D.P.,
- Title:Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.
- Journal:J. Biol. Chem., 1994, 269, 10849-10855 [MEDLINE:94193792]
- [2] Grassy G.,Chiche L.,Roch P.,Chavanieu A.,Vignal E.,
- Title:Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles.
- Journal:Eur. J. Biochem., 1998, 253, 221-228 [MEDLINE:98237592]
Comments
- Comments
No comments found on LAMP database