Record in detail


General Info

  • lamp_id:L01A000654
  • Name:RLXN_LITCT
  • FullName:Ranalexin
  • Source:Lithobates catesbeiana
  • Mass:1958.5 Da
  • Sequence Length:19 aa
  • Isoelectric Point:9.67
  • Activity:Antibacterial
  • Sequence
        LGGLIKIVPAMICAVTKKC
  • Function:Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000117    From 48 To 66 E-value: 0.000006 Score: 40.8
        LGGLIKIVPAMICAVTKKC
  • 2. L11A009230    From 2 To 20 E-value: 0.00001 Score: 40
        LGGLIKIVPAMICAVTKKC
  • 3. L01A000650    From 2 To 20 E-value: 0.00003 Score: 38.9
        LGGLIKIVPAMICAVTKKC
  • 4. L01A000654    From 1 To 19 E-value: 0.00003 Score: 38.5
        LGGLIKIVPAMICAVTKKC
  • 5. L01A000653    From 1 To 18 E-value: 0.00008 Score: 37.4
        GGLIKIVPAMICAVTKKC

Structure

  •   Domains
  •   1  Name:Antimicrobial_frog_1    Interpro Link:IPR012520
  •   2  Name:Brevinin    Interpro Link:IPR004275
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S.aureus  MIC:  256 μg/ml  (130.712 μM)  
  •   2  Target:  E.coli  MIC:  256 μg/ml  (130.712 μM)  
  •   3  Target:  P.aeruginosa  MIC:  256 μg/ml  (130.712 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Zasloff M.,Maloy W.L.,Durell S.,Clark D.P.,
  •   Title:Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.
  •   Journal:J. Biol. Chem., 1994, 269, 10849-10855  [MEDLINE:94193792]
  •   [2]  Grassy G.,Chiche L.,Roch P.,Chavanieu A.,Vignal E.,
  •   Title:Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles.
  •   Journal:Eur. J. Biochem., 1998, 253, 221-228  [MEDLINE:98237592]

Comments

  •   Comments

    •     No comments found on LAMP database



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