Record in detail


General Info

  • lamp_id:L01A000670
  • Name:LANNA_STAWA
  • FullName:Lantibiotic nukacin
  • Source:Staphylococcus warneri
  • Mass:3031.5 Da
  • Sequence Length:27 aa
  • Isoelectric Point:8.53
  • Activity:Antibacterial
  • Sequence
        KKKSGVIPTVSHDCHMNSFQFVFTCCS
  • Function:Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria, such as Lactobacillus sakei, Leuconostoc mesenteroides and Pediococcus pentosaceus. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06774|    From 31 To 57 E-value: 0.000000000007 Score: 60.8
        KKKSGVIPTVSHDCHMNSFQFVFTCCS
  • 2. L01A000670    From 1 To 27 E-value: 0.00000000006 Score: 58.2
        KKKSGVIPTVSHDCHMNSFQFVFTCCS
  • 3. L12A05145|    From 1 To 26 E-value: 0.0000000007 Score: 54.3
        KKSGVIPTVSHDCHMNTFQFMFTCCS
  • 4. L12A09475|    From 24 To 47 E-value: 0.000000003 Score: 52.4
        SGVIPTISHECHMNSFQFVFTCCS
  • 5. L01A003116    From 2 To 25 E-value: 0.000000008 Score: 50.8
        SGVIPTISHECHMNSFQFVFTCCS

Structure

  •   Domains
  •   1  Name:Lantibiotic_typ-A    Interpro Link:IPR007682
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Ishizaki A.,Sonomoto K.,Sashihara T.,Matsusaki H.,Kimura H.,
  •   Title:Purification and partial identification of bacteriocin ISK-1, a new lantibiotic produced by Pediococcus sp. ISK-1.
  •   Journal:Biosci. Biotechnol. Biochem., 1998, 62, 2341-2345  [:]
  •   [2]  Matsusaki H.,Adachi A.,Higuchi T.,Kimura H.,Sashihara T.,
  •   Title:A novel lantibiotic, nukacin ISK-1, of Staphylococcus warneri ISK-1: cloning of the structural gene and identification of the structure.
  •   Journal:Biosci. Biotechnol. Biochem., 2000, 64, 2420-2428  [MEDLINE:21036904]
  •   [3]  Koga H.,Kanemasa Y.,Nagao J.,Sashihara T.,Aso Y.,
  •   Title:Characterization of a gene cluster of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.
  •   Journal:Biosci. Biotechnol. Biochem., 2004, 68, 1663-1671  [PubMed:15322349]
  •   [4]  Kanemasa Y.,Okuda K.,Koga H.,Nagao J.,Aso Y.,
  •   Title:Heterologous expression and functional analysis of the gene cluster for the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.
  •   Journal:J. Biosci. Bioeng., 2004, 98, 429-436  [PubMed:16233732]
  •   [5]  Kanemasa Y.,Nagao J.,Sashihara T.,Koga H.,Aso Y.,
  •   Title:Description of complete DNA sequence of two plasmids from the nukacin ISK-1 producer, Staphylococcus warneri ISK-1.
  •   Journal:Plasmid, 2005, 53, 164-178  [PubMed:15737403]
  •   [6]  Sonomoto K.,Nakayama J.,Aso Y.,Nagao J.,Asaduzzaman S.M.,
  •   Title:Lysine-oriented charges trigger the membrane binding and activity of nukacin ISK-1.
  •   Journal:Appl. Environ. Microbiol., 2006, 72, 6012-6017  [PubMed:16957223]

Comments

  •   Comments

    •     No comments found on LAMP database



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