Record in detail

lamp_id:L01A000671
Name:ENA2_HORSE
FullName:Antimicrobial peptide eNAP-2
Source:Equus caballus
Mass:4769.4 Da
Sequence Length:46 aa
Isoelectric Point:8.13
Activity:Antibacterial
Sequence
EVERKHPLGGSRPGRCPTVPPGTFGHCACLCTGDASEPKGQKCCSN
Function:Has antibiotic activity against several equine uterine pathogens; S.zooepidemicus, E.coli and P.aeruginosa. Highly efficient against S.zoopedemicus. Not active against K.pneumoniae. Selectively inactivates microbial serine proteases (subtilisin A and proteinase K) without inhibiting mammalian serine proteases (human neutrophil elastase, human cathepsin G and bovine pancreatic trypsin).

Top similar AMPs on LAMP
1. L01A000671 From 1 To 46 E-value: 6e-22 Score: 94.4
EVERKHPLGGSRPGRCPTVPPGTFGHCACLCTGDASEPKGQKCCSN
2. L01A003582 From 4 To 40 E-value: 0.06 Score: 28.1
RPGSCPNVDVPIPPLGLCRTTCQTDANCQEGRKCCKN
3. L01A003633 From 3 To 39 E-value: 0.24 Score: 26.2
KSGSCPDMSMPIPPLGICKTLCNSDSGCPNVQKCCKN
4. L01A003579 From 4 To 40 E-value: 0.78 Score: 24.3
KAGSCPDVNQPIPPLGLCRNMCESDSGCPNNEKCCKN
5. L01A003580 From 4 To 40 E-value: 0.94 Score: 23.9
KAGSCPDVNQPIPPLGVCKTTCATDSNCPDIQKCCKN

Reference
[1] Lehrer R.I.,Hughes J.P.,Cullor J.S.,Harwig S.S.L.,Couto M.A.,
Title:eNAP-2, a novel cysteine-rich bactericidal peptide from equine leukocytes.
Journal:Infect. Immun., 1992, 60, 5042-5047 [MEDLINE:93084348]
[2] Lehrer R.I.,Harwig S.S.L.,Couto M.A.,
Title:Selective inhibition of microbial serine proteases by eNAP-2, an antimicrobial peptide from equine neutrophils.
Journal:Infect. Immun., 1993, 61, 2991-2994 [MEDLINE:93293322]