Record in detail


General Info

  • lamp_id:L01A000672
  • Name:SPING_PSEUS
  • FullName:Spingerin
  • Source:Pseudacanthotermes spiniger
  • Mass:3000.7 Da
  • Sequence Length:25 aa
  • Isoelectric Point:11.72
  • Activity:Antibacterial, Antifungal
  • Sequence
        HVDKKVADKVLLLKQLRIMRLLTRL
  • Function:Active against Gram-positive bacteria B.megaterium and M.luteus, Gram-negative bacteria E.coli SBS363 and D22, K.pneumoniae, S.typhimurium and P.aeruginosa, yeast C.albicans and filamentous fungi F.culmorum, N.crassa, N.hematococca and T.viridae. Inactive against Gram-positive bacteria B.subtilis, S.pyogenes, B.thuringiensis and S.aureus, Gram-negative bacteria E.cloacae and E.carotovora and filamentous fungus B.bassiana.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L11A006505    From 35 To 59 E-value: 0.00000005 Score: 48.1
        HVDKKVADKVLLLKQLRIMRLLTRL
  • 2. L11A006503    From 33 To 57 E-value: 0.00000009 Score: 47.4
        HVDKKVADKVLLLKQLRIMRLLTRL
  • 3. L01A000672    From 1 To 25 E-value: 0.0000001 Score: 47
        HVDKKVADKVLLLKQLRIMRLLTRL
  • 4. L13A016846    From 1 To 21 E-value: 0.00001 Score: 40.4
        HVDKKVADKVLLLKQLRIMRL
  • 5. L12A05150|    From 1 To 22 E-value: 0.00002 Score: 40
        KKVADKVLLLKQLRIMRLLTRL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  B. megaterium  MIC:  2.4 μg/ml  (0.799813 μM)  
  •   2  Target:  M. luteus  MIC:  2.4 μg/ml  (0.799813 μM)  
  •   3  Target:  E. coli SBS363  MIC:  9 μg/ml  (2.9993 μM)  
  •   4  Target:  E. coli D22  MIC:  9 μg/ml  (2.9993 μM)  
  •   5  Target:  K. pneumoniae  MIC:  150.04 μg/ml  (50.0017 μM)  
  •   6  Target:  S. typhimurium  MIC:  9 μg/ml  (2.9993 μM)  
  •   7  Target:  P. aeruginosa  MIC:  150.04 μg/ml  (50.0017 μM)  
  •   8  Target:  T. viride  MIC:  4.5 μg/ml  (1.49965 μM)  
  •   9  Target:  N. crassa ( MIC = 3-6 �M F.culmorum  MIC:  4.5 μg/ml  (1.49965 μM)  
  •   10  Target:  N. haematococca  MIC:  1.2 μg/ml  (0.399907 μM)  
  •   11  Target:  C. albicans  MIC:  9 μg/ml  (2.9993 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Robert A.,Bordereau C.,Lanot R.,Zachary D.,Lamberty M.,
  •   Title:Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect.
  •   Journal:J. Biol. Chem., 2001, 276, 4085-4092  [PubMed:11053427]
  •   [2]  Vovelle F.,Bulet P.,Boulanger N.,Meudal H.,Landon C.,
  •   Title:Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation.
  •   Journal:Biopolymers, 2006, 81, 92-103  [PubMed:16170803]

Comments

  •   Comments

    •     No comments found on LAMP database



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