Record in detail


General Info

  • lamp_id:L01A000696
  • Name:DEF_PHACN
  • FullName:Defensin-like protein
  • Source:Phaseolus coccineus
  • Mass:1182.2 Da
  • Sequence Length:10 aa
  • Isoelectric Point:4.19
  • Activity:Antifungal, Antiviral
  • Sequence
        KQTENLADTY
  • Function:Has strong antifungal activity against F.oxysporum, M.arachidicola and P.piricola, and weaker antifungal activity against B.cinerea, C.comatus and R.solani. Exerts antifungal activity against M.arachidicola with an IC(50) of 75uM. Inhibits the proliferation of leukemia cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase. Lacks mitogenic activity towards murine splenocytes.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000696    From 1 To 10 E-value: 0.55 Score: 23.5
        KQTENLADTY
  • 2. L02A001677    From 1 To 10 E-value: 6.2 Score: 20
        KTCENLADTY
  • 3. L11A002570    From 29 To 38 E-value: 6.5 Score: 20
        KTCENLADTY
  • 4. L07APD0118    From 1 To 10 E-value: 7 Score: 19.6
        KTCENLADTY
  • 5. L07APD0170    From 1 To 10 E-value: 7.9 Score: 19.6
        KTCENLADTY

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  F.oxysporum M.arachidicola P.piricola B.cinerea   IC50:  88.66 μg/ml  (74.9958 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Ng T.B.,Ngai P.H.,
  •   Title:Coccinin, an antifungal peptide with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from large scarlet runner beans.
  •   Journal:Peptides, 2004, 25, 2063-2068  [PubMed:15572193]

Comments

  •   Comments

    •     No comments found on LAMP database



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