Record in detail
General Info
- lamp_id:L01A000697
- Name:AFAGR_AGRCY
- FullName:Agrocybin
- Source:Agrocybe cylindracea
- Mass:1610.8 Da
- Sequence Length:15 aa
- Isoelectric Point:6.18
- Activity:Antibacterial, Antifungal, Antiviral
- Sequence
ANDPQCLYGNVAAKF - Function:Has antifungal activity against M.arachidicola with an IC(50) of 125 uM, but not against F.oxysporum. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase with an IC(50) of 60 uM. Has mitogenic activity towards murine splenocytes. Lacks antiproliferative activity towards HepG2 hepatoma cells. Has antibacterial activity against the Gram-negative bacterium P.fluorescens. No antibacterial activity against the Gram-positive bacteria B.subtilis, B.cereus, B.megaterium, M.phei and S.aureus, or against the Gram-negative bacteria E.aerogenes, E.coli, P.aeruginosa, P.fluorescens and P.vulgaris.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ653
- 2 Database:DBAASP 1666
- 3 Database:dbAMP dbAMP_00421
- 4 Database:DRAMP DRAMP03778
- 5 Database:SATPdb satpdb19233
- 6 Database:Uniprot P84797
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000697 From 1 To 15 E-value: 0.0003 Score: 34.7
ANDPQCLYGNVAAKF
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
- 1 Target: M. arachidicola IC50: 201.35 μg/ml (125 μM)
- 2 Target: HIV-1 reverse transcriptase IC50: 96.65 μg/ml (60.0012 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Ng T.B.,Zhao Z.,Ngai P.H.,
- Title:Agrocybin, an antifungal peptide from the edible mushroom Agrocybe cylindracea.
- Journal:Peptides, 2005, 26, 191-196 [PubMed:15629530]
Comments
- Comments
No comments found on LAMP database