Record in detail


General Info

  • lamp_id:L01A000709
  • Name:MRJP1_APIME
  • FullName:Major royal jelly protein 1
  • Source:Apis mellifera
  • Mass:954.2 Da
  • Sequence Length:8 aa
  • Isoelectric Point:9.69
  • Activity:Antibacterial, Antifungal
  • Sequence
        PFKISIHL
  • Function:Major royal jelly protein 1: induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The royal jelly determines the development of the young larvae and is responsible for the high reproductive ability of the honeybee queen.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L11A007636    From 2 To 9 E-value: 5.2 Score: 20
        PFKISIHL
  • 2. L11A007637    From 2 To 9 E-value: 5.2 Score: 20
        PFKISIHL
  • 3. L01A000710    From 2 To 9 E-value: 6 Score: 19.6
        PFKISIHL
  • 4. L01A000691    From 2 To 9 E-value: 6.2 Score: 19.6
        PFKISIHL
  • 5. L01A000709    From 1 To 8 E-value: 6.5 Score: 19.6
        PFKISIHL

Structure

  •   Domains
  •   1  Name:6-blade_b-propeller_TolB-like    Interpro Link:IPR011042
  •   2  Name:Royal_jelly    Interpro Link:IPR017996
  •   3  Name:Royal_jelly-related    Interpro Link:IPR003534
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S. aureus ATCC 6535  MIC:  10 μg/ml  (10.48 μM)  
  •   2  Target:  S. saprophyticus  MIC:  15 μg/ml  (15.72 μM)  
  •   3  Target:  B. subtilis CCT 2471  MIC:  10 μg/ml  (10.48 μM)  
  •   4  Target:  E. coli CCT 1371  MIC:  2.5 μg/ml  (2.62 μM)  
  •   5  Target:  E. cloacae ACCT 23355  MIC:  10 μg/ml  (10.48 μM)  
  •   6  Target:  K. pneumoniae ACCT 13883  MIC:  10 μg/ml  (10.48 μM)  
  •   7  Target:  Pseudomonas aeruginsa ACCT 27853  MIC:  10 μg/ml  (10.48 μM)  
  •   8  Target:  C. albicans  MIC:  2.5 μg/ml  (2.62 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Kubo T.,Natori S.,Ohashi K.,
  •   Title:Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.
  •   Journal:Eur. J. Biochem., 1997, 249, 797-802  [MEDLINE:98055707]
  •   [2]  Schreckengost W.,Schroeder W.,Albert S.,Klaudiny J.,Schmitzova J.,
  •   Title:A family of major royal jelly proteins of the honeybee Apis mellifera L.
  •   Journal:Cell. Mol. Life Sci., 1998, 54, 1020-1030  [MEDLINE:99007754]
  •   [3]  Yonekura M.,Fukushima M.,Fukuda T.,Kamakura M.,
  •   Title:Storage-dependent degradation of 57-kDa protein in royal jelly: a possible marker for freshness.
  •   Journal:Biosci. Biotechnol. Biochem., 2001, 65, 277-284  [PubMed:11302159]
  •   [4]  Judova J.,Janitz M.,O"Brien J.K.,Ramser J.,Malecova B.,
  •   Title:Honeybee (Apis mellifera L.) mrjp gene family: computational analysis of putative promoters and genomic structure of mrjp1, the gene coding for the most abundant protein of larval food.
  •   Journal:Gene, 2003, 303, 165-175  [MEDLINE:22448659]
  •   [5]  Cesar L.M.,Konno K.,de Souza B.M.,Mendes M.A.,Fontana R.,
  •   Title:Jelleines: a family of antimicrobial peptides from the royal jelly of honeybees (Apis mellifera).
  •   Journal:Peptides, 2004, 25, 919-928  [PubMed:15203237]
  •   [6]  Sakaki T.,Kamakura M.,
  •   Title:A hypopharyngeal gland protein of the worker honeybee Apis mellifera L. enhances proliferation of primary-cultured rat hepatocytes and suppresses apoptosis in the absence of serum.
  •   Journal:Protein Expr. Purif., 2006, 45, 307-314  [PubMed:16290177]
  •   [7]  Kamakura M.
  •   Title:Royalactin induces queen differentiation in honeybees.
  •   Journal:Nature, 2011, 473, 478-483  [PubMed:21516106]

Comments

  •   Comments

    •     No comments found on LAMP database



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