Record in detail


General Info

  • lamp_id:L01A000729
  • Name:M5H43_BOMMX
  • FullName:Maximins 5/H4 type 3
  • Source:Bombina maxima
  • Mass:1961.4 Da
  • Sequence Length:20 aa
  • Isoelectric Point:10.8
  • Activity:Antibacterial, Antifungal
  • Sequence
        ILGPVISKIGGVLGGLLKNL
  • Function:Maximin-5 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. The only exception is the resistance of E.coli. Shows also antimicrobial activity against fungi C.albicans, A.flavus and P.uticale. It has little hemolytic activity. It does not possess a significant cytotoxicity against tumor cell lines. It does not possess a significant anti-HIV activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000729    From 1 To 20 E-value: 0.0001 Score: 36.6
        ILGPVISKIGGVLGGLLKNL
  • 2. L13A024991    From 1 To 19 E-value: 0.0003 Score: 35.4
        ILGPVISKIGGVLGGLLKN
  • 3. L01A000280    From 1 To 20 E-value: 0.0004 Score: 35
        ILGPVISTIGGVLGGLLKNL
  • 4. L13A023714    From 1 To 20 E-value: 0.0009 Score: 33.9
        ILGPVISKIGVVLGGLLKNL
  • 5. L13A022149    From 1 To 19 E-value: 0.001 Score: 33.9
        ILGPVISTIGGVLGGLLKN

Structure

  •   Domains
  •   1  Name:Bombinin    Interpro Link:IPR007962
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  Escherichia coli ATCC25922  MIC:  12 μg/ml  (6.11808 μM)  
  •   2  Target:  Staphylococcus aureus ATCC2592  MIC:  6 μg/ml  (3.05904 μM)  
  •   3  Target:  Bacillus pyocyaneus CMCCB1010  MIC:  12 μg/ml  (6.11808 μM)  
  •   4  Target:  Candida albicans ATCC2002  MIC:  6 μg/ml  (3.05904 μM)  
  •   5  Target:  E. coli  MIC:  12.0038 μg/ml  (6.12 μM)  
  •   6  Target:  S. aureus  MIC:  6.00188 μg/ml  (3.06 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Liu H.,Liu G.-J.,Shen J.-H.,Zheng Y.-T.,Lai R.,
  •   Title:Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
  •   Journal:Peptides, 2002, 23, 427-435  [MEDLINE:21826911]
  •   [2]  Zhang Y.,Li S.,Lai R.,Li Y.,Lee W.-H.,
  •   Title:Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
  •   Journal:Eur. J. Immunol., 2005, 35, 1220-1229  [PubMed:15770703]

Comments

  •   Comments

    •     No comments found on LAMP database



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