Record in detail

General Info

lamp_id:L01A001801
Name:DEF1_HUMAN
FullName:Neutrophil defensin 1
Source:Homo sapiens
Mass:3448 Da
Sequence Length:30 aa
Isoelectric Point:8.37
Activity:Antibacterial,Anticancer
Sequence
ACYCRIPACIAGERRYGTCIYQGRLWAFCC
Function:Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

Cross-Linking

Cross-linking
1 Database:APD 176
2 Database:CAMP CAMPSQ692
3 Database:DBAASP 759
4 Database:dbAMP dbAMP_00119
5 Database:DRAMP DRAMP03591
6 Database:SATPdb satpdb27556
7 Database:Uniprot P59665
8 Database:DEF DEF51
9 Database:RAP RAPD0001
10 Database:RAP RAPD0002
11 Database:RAP RAPD0075

Top similar AMPs

Top similar AMPs on LAMP
1. L03A000277 From 65 To 94 E-value: 0.00000000000009 Score: 67.4
ACYCRIPACIAGERRYGTCIYQGRLWAFCC
2. L12A09210| From 65 To 94 E-value: 0.0000000000001 Score: 67.4
ACYCRIPACIAGERRYGTCIYQGRLWAFCC
3. L12A09209| From 66 To 94 E-value: 0.0000000000002 Score: 66.2
CYCRIPACIAGERRYGTCIYQGRLWAFCC
4. L12A09208| From 66 To 94 E-value: 0.0000000000002 Score: 65.9
CYCRIPACIAGERRYGTCIYQGRLWAFCC
5. L12A01083| From 27 To 56 E-value: 0.0000000000005 Score: 65.1
ACYCRIPACIAGERRYGTCIYQGRLWAFCC

Structure

Domains
1 Name:Alpha-defensin Interpro Link:IPR016327
2 Name:Defensin_beta/neutrophil Interpro Link:IPR006080
3 Name:Defensin_propep Interpro Link:IPR002366
4 Name:Mammalian_defensins Interpro Link:IPR006081

Structures

1
PDB:2KHT
Method:NMR
Chains:A=65-94
2
PDB:2PM1
Method:X-ray
Chains:A=65-94
3
PDB:3GNY
Method:X-ray
Chains:A/B=65-94
4
PDB:3H6C
Method:X-ray
Chains:A/B=65-94
5
PDB:3HJ2
Method:X-ray
Chains:A/B=65-94
6
PDB:3HJD
Method:X-ray
Chains:A/B=65-94
7
PDB:3LO1
Method:X-ray
Chains:A=65-94
8
PDB:3LO2
Method:X-ray
Chains:A/B=65-94
9
PDB:3LO4
Method:X-ray
Chains:A/B=65-94
10
PDB:3LO6
Method:X-ray
Chains:A/B=65-94
11
PDB:3LO9
Method:X-ray
Chains:A/B=65-94
12
PDB:3LOE
Method:X-ray
Chains:A=65-94
13
PDB:3LVX
Method:X-ray
Chains:A/B=65-94
14
PDB:4DU0
Method:X-ray
Chains:A/B/C/D=65-94

Activity

Antibacterial Activities

Toxicity

Toxicity

Reference

Reference
[1] Ganz T.,Liu L.,Michaelson D.,Linzmeier R.,
Title:
Journal:FEBS Lett., 1993, 326, 299-300 [MEDLINE:93314809]
[2] Lehrer R.I.,Schilling J.W.,Ganz T.,Harwig S.S.L.,Selsted M.E.,
Title:Primary structures of three human neutrophil defensins.
Journal:J. Clin. Invest., 1985, 76, 1436-1439 [MEDLINE:86034582]
[3] Saunders G.F.,White J.W.,Drabkin H.A.,vanTuinen P.,Mars W.M.,
Title:A myeloid-related sequence that localizes to human chromosome 8q21.1-22.
Journal:Blood, 1988, 71, 1713-1719 [MEDLINE:88222410]
[4] Kronenberg M.,Ganz T.,Lehrer R.I.,Daher K.A.,
Title:Isolation and characterization of human defensin cDNA clones.
Journal:Proc. Natl. Acad. Sci. U.S.A., 1988, 85, 7327-7331 [MEDLINE:89017191]
[5] Harwig S.S.L.,Selsted M.E.,
Title:Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide.
Journal:J. Biol. Chem., 1989, 264, 4003-4007 [MEDLINE:89139465]
[6] Winnie J.N.,Burns J.H.,Lamb R.F.,Francis G.E.,Wiedemann L.M.,
Title:Differentiation stage-specific expression of a gene during granulopoiesis.
Journal:Leukemia, 1989, 3, 227-234 [MEDLINE:89142618]
[7] Solomon S.,Mars W.M.,Shustik C.,Singh A.,Bateman A.,
Title:The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells.
Journal:J. Biol. Chem., 1991, 266, 7524-7530 [MEDLINE:91210262]
[8] Pardi A.,Selsted M.E.,Zhang X.-L.,
Title:NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1.
Journal:Biochemistry, 1992, 31, 11348-11356 [MEDLINE:93075733]
[9] Yip P.F.,Skalicky J.J.,Selsted M.E.,Zhang X.-L.,Pardi A.,
Title:NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1.
Journal:Biochemistry, 1992, 31, 11357-11364 [MEDLINE:93075734]
[10] Ganz T.,Valore E.V.,
Title:Posttranslational processing of defensins in immature human myeloid cells.
Journal:Blood, 1992, 79, 1538-1544 [MEDLINE:92190492]
[11] Ganz T.,Liu L.,Michaelson D.,Linzmeier R.,
Title:The structure of neutrophil defensin genes.
Journal:FEBS Lett., 1993, 321, 267-273 [MEDLINE:93238968]
[12] Weil M.M.,Huff V.,Maity T.,Patmasiriwat P.,Mars W.M.,
Title:Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3.
Journal:J. Biol. Chem., 1995, 270, 30371-30376 [MEDLINE:96107186]
[13] Henzel W.J.,Zhang Z.,
Title:Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Journal:Protein Sci., 2004, 13, 2819-2824 [PubMed:15340161]
[14]
Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Journal:Genome Res., 2004, 14, 2121-2127 [PubMed:15489334]
[15] Lehrer R.I.,Lu W.,Wu Z.,Ericksen B.,
Title:Antibacterial activity and specificity of the six human alpha-defensins.
Journal:Antimicrob. Agents Chemother., 2005, 49, 269-275 [PubMed:15616305]
[16] Taudien S.,Asakawa S.,Zody M.C.,Mikkelsen T.S.,Nusbaum C.,
Title:DNA sequence and analysis of human chromosome 8.
Journal:Nature, 2006, 439, 331-335 [PubMed:16421571]
[17] Yu J.,Possemato A.,Zeng Q.,Guo A.,Rikova K.,
Title:Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Journal:Cell, 2007, 131, 1190-1203 [PubMed:18083107]
[18] Li C.,Pazgier M.,Li C.,de Leeuw E.,Zou G.,
Title:Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
Journal:J. Biol. Chem., 2007, 282, 19653-19665 [PubMed:17452329]
[19] Talluri E.,Pogni R.,Picchianti M.,Bonucci A.,Balducci E.,
Title:Structural and functional consequences induced by post-translational modifications in alpha-Defensins.
Journal:Int. J. Pept., 2011, 2011, 594723-594723 [PubMed:21904558]

Comments

Comments