Record in detail

General Info

lamp_id:L01A001811
Name:GRAH1_RANGR
FullName:Grahamin-1
Source:Rana grahami
Mass:1945.3 Da
Sequence Length:21 aa
Isoelectric Point:8.23
Activity:Antibacterial, Antifungal
Sequence
GLLSGILGAGKNIVCGLSGLC
Function:Potent microbicidal activity, active against the Gram positive bacterium S.aureus and against the Gram-negative bacteria E.coli and B.dysenteriae. Has antifungal activity against C.albicans. Lacks hemolytic activity against rabbit erythrocytes.

Cross-Linking

Cross-linking
1 Database:APD 581
2 Database:CAMP CAMPSQ699
3 Database:DBAASP 2197
4 Database:dbAMP dbAMP_03609
5 Database:DRAMP DRAMP01419
6 Database:SATPdb satpdb12798
7 Database:Uniprot P85071

Top similar AMPs

Top similar AMPs on LAMP
1. L12A07348| From 47 To 67 E-value: 0.000003 Score: 42
GLLSGILGAGKNIVCGLSGLC
2. L12A07186| From 46 To 66 E-value: 0.00001 Score: 40
GLLSGILGAGKHIVCGLSGLC
3. L01A001811 From 1 To 21 E-value: 0.00002 Score: 39.3
GLLSGILGAGKNIVCGLSGLC
4. L01A003163 From 1 To 21 E-value: 0.00006 Score: 37.7
GLLSGILGAGKHIVCGLSGLC
5. L13A027179 From 1 To 21 E-value: 0.00006 Score: 37.7
GLLSGTLGAGKNIVCGLSGLC

Structure

Domains
1 Name:Brevinin Interpro Link:IPR004275

Structures

Activity

Antibacterial Activities
1 Target: [ Refer PubMed 17272268 : - E. coli MIC: 100 μg/ml (51.406 μM)
2 Target: S. aureus MIC: 75 μg/ml (38.5545 μM)
3 Target: B. subtilis MIC: 9.37 μg/ml (4.81674 μM)
4 Target: C.albicans MIC: 9.37 μg/ml (4.81674 μM)
5 Target: ] [ Refer PubMed 16621155 :- E. coli MIC: 48.63 μg/ml (24.9987 μM)
6 Target: S. aureus MIC: 194.53 μg/ml (100 μM)
7 Target: C. albicans MIC: 194.53 μg/ml (100 μM)
8 Target: E. coli MIC: 7.50886 μg/ml (3.86 μM)
9 Target: S. aureus MIC: 2.50944 μg/ml (1.29 μM)

Toxicity

Toxicity

Reference

Reference
[1] Liang J.,Yang H.,Han Y.,Li J.,Xu X.,
Title:Two antimicrobial peptides from skin secretions of Rana grahami.
Journal:Toxicon, 2006, 47, 459-464 [PubMed:16487561]

Comments

Comments