Record in detail


General Info

  • lamp_id:L01A002371
  • Name:DMS6_PHYAZ
  • FullName:Dermaseptin-H6
  • Source:Phyllomedusa azurea
  • Mass:2795.2 Da
  • Sequence Length:29 aa
  • Isoelectric Point:10.8
  • Activity:Antibacterial
  • Sequence
        GLWSTIKQKGKEAAIAAAKAAGQAALGAL
  • Function:Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002371    From 1 To 29 E-value: 0.000000003 Score: 52
        GLWSTIKQKGKEAAIAAAKAAGQAALGAL
  • 2. L13A023847    From 1 To 28 E-value: 0.00000001 Score: 50.4
        GLWSTIKQKGKEAAIAAAKAAGQAALGA
  • 3. L12A05358|    From 41 To 65 E-value: 0.0005 Score: 35
        GLWSTIKNVGKEAAI----AAGKAVLGSL
  • 4. L01A003280    From 1 To 25 E-value: 0.0008 Score: 34.3
        GLWSTIKNVGKEAAI----AAGKAVLGSL
  • 5. L02A001352    From 1 To 25 E-value: 0.001 Score: 33.9
        GLWSTIKNVGKEAAI----AAGKAVLGSL

Structure

  •   Domains
  •   1  Name:Dermaseptin    Interpro Link:IPR022731
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  17.9452 μg/ml  (6.42 μM)  
  •   2  Target:  S. aureus  MIC:  8.94464 μg/ml  (3.2 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  McClean S.,Shaw C.,Orr D.F.,Bjourson A.J.,Thompson A.H.,
  •   Title:A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.
  •   Journal:Peptides, 2007, 28, 1331-1343  [PubMed:17553595]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: