Record in detail
General Info
- lamp_id:L01A002378
- Name:H2B3_ICTPU
- FullName:Histone H2B 3
- Source:Ictalurus punctatus
- Mass:1795.1 Da
- Sequence Length:17 aa
- Isoelectric Point:11.1
- Activity:Antibacterial, Antifungal
- Sequence
PDPAKTAPKKKSKKAVT - Function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cross-Linking
- Cross-linking
- 1 Database:APD 337
- 2 Database:CAMP CAMPSQ1236
- 3 Database:dbAMP dbAMP_09880
- 4 Database:DRAMP DRAMP02387
- 5 Database:SATPdb satpdb15552
- 6 Database:Uniprot P81904
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L12A08890| From 2 To 18 E-value: 0.002 Score: 32
PDPAKTAPKKKSKKAVT - 2. L01A002378 From 1 To 17 E-value: 0.003 Score: 32
PDPAKTAPKKKSKKAVT - 3. L12A08889| From 2 To 18 E-value: 0.008 Score: 30.4
PDPAKTAPKKGSKKAVT - 4. L01A002379 From 1 To 17 E-value: 0.009 Score: 30.4
PDPAKTAPKKGSKKAVT - 5. L02A000338 From 1 To 17 E-value: 0.009 Score: 30.4
PDPAKTAPKKGSKKAVT
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Miller W.L.,Levy M.G.,Arroll T.,Wada S.,Robinette D.,
- Title:Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins.
- Journal:Cell. Mol. Life Sci., 1998, 54, 467-475 [MEDLINE:98309109]
Comments
- Comments
No comments found on LAMP database