Record in detail


General Info

  • lamp_id:L01A002379
  • Name:H2B1_ICTPU
  • FullName:Histone H2B 1
  • Source:Ictalurus punctatus
  • Mass:1980.3 Da
  • Sequence Length:20 aa
  • Isoelectric Point:11.1
  • Activity:Antibacterial, Antifungal
  • Sequence
        PDPAKTAPKKGSKKAVTKXA
  • Function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A08889|    From 2 To 21 E-value: 0.0002 Score: 35.8
        PDPAKTAPKKGSKKAVTKXA
  • 2. L01A002379    From 1 To 20 E-value: 0.0003 Score: 35.4
        PDPAKTAPKKGSKKAVTKXA
  • 3. L02A000338    From 1 To 18 E-value: 0.0005 Score: 34.7
        PDPAKTAPKKGSKKAVTK

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Miller W.L.,Levy M.G.,Arroll T.,Wada S.,Robinette D.,
  •   Title:Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins.
  •   Journal:Cell. Mol. Life Sci., 1998, 54, 467-475  [MEDLINE:98309109]

Comments

  •   Comments

    •     No comments found on LAMP database



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