Record in detail


General Info

  • lamp_id:L01A002444
  • Name:DEFI_ANOGA
  • FullName:Defensin
  • Source:Anopheles gambiae
  • Mass:4141.7 Da
  • Sequence Length:40 aa
  • Isoelectric Point:8.62
  • Activity:Antibacterial
  • Sequence
        ATCDLASGFGVGSSLCAAHCIARRYRGGYCNSKAVCVCRN
  • Function:Responsible for the anti Gram-positive activity of immune hemolymph (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002444    From 1 To 40 E-value: 1e-17 Score: 80.5
        ATCDLASGFGVGSSLCAAHCIARRYRGGYCNSKAVCVCRN
  • 2. L05ADEF511    From 1 To 40 E-value: 5e-17 Score: 78.2
        ATCDLASGFGVGSSLCAAHCIARRYRGGYCNSQQVCVCRN
  • 3. L12A09253|    From 60 To 99 E-value: 0.000000000000005 Score: 71.6
        ATCDLLSGFGVGDSACAAHCIARRNRGGYCNAKKVCVCRN
  • 4. L12A00605|    From 1 To 40 E-value: 0.000000000000006 Score: 71.2
        ATCDLASIFNVNHALCAAHCIARRYRGGYCNSKAVCVCRN
  • 5. L03A000168    From 59 To 98 E-value: 0.00000000000002 Score: 69.7
        ATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCRN

Structure

  •   Domains
  •   1  Name:Defensin_invertebrate/fungal    Interpro Link:IPR001542
  •   2  Name:Knot1    Interpro Link:IPR003614
  •   Structures

Activity

  •   Antibacterial Activities

  •     No MICs found on LAMP database

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Hoffmann J.A.,Barillas-Mury C.,Hetru C.,Bulet P.,Richman A.M.,
  •   Title:Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA.
  •   Journal:Insect Mol. Biol., 1996, 5, 203-210  [MEDLINE:96392951]
  •   [2]  Zhao Y.,Lu W.,Eggleston P.,
  •   Title:Genomic organization and immune regulation of the defensin gene from the mosquito, Anopheles gambiae.
  •   Journal:Insect Mol. Biol., 2000, 9, 481-490  [PubMed:11029666]
  •   [3]  Charlab R.,Sutton G.G.,Halpern A.,Subramanian G.M.,Holt R.A.,
  •   Title:The genome sequence of the malaria mosquito Anopheles gambiae.
  •   Journal:Science, 2002, 298, 129-149  [MEDLINE:22251359]
  •   [4]  Vovelle F.,Guenneugues M.,Legrain M.,Barbault F.,Landon C.,
  •   Title:Rational design of peptides active against the gram positive bacteria Staphylococcus aureus.
  •   Journal:Proteins, 2008, 72, 229-239  [PubMed:18214975]

Comments

  •   Comments

  •     No comments found on LAMP database



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