Record in detail


General Info

  • lamp_id:L01A002448
  • Name:LANA_RUMHA
  • FullName:Ruminococcin-A
  • Source:Ruminococcus hansenii
  • Mass:2747.2 Da
  • Sequence Length:24 aa
  • Isoelectric Point:7.18
  • Activity:Antibacterial
  • Sequence
        GNGVLKTISHECNMNTWQFLFTCC
  • Function:Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Ruminococcin A is a broad spectrum bacteriocin exhibiting activity against a wide range of pathogenic clostridia and B.longum (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A09160|    From 24 To 47 E-value: 0.0000000006 Score: 54.7
        GNGVLKTISHECNMNTWQFLFTCC
  • 2. L12A09161|    From 24 To 47 E-value: 0.0000000006 Score: 54.3
        GNGVLKTISHECNMNTWQFLFTCC
  • 3. L01A002448    From 1 To 24 E-value: 0.000000001 Score: 53.1
        GNGVLKTISHECNMNTWQFLFTCC
  • 4. L12A08789|    From 24 To 47 E-value: 0.000000007 Score: 51.2
        GNGVIKTISHECHMNTWQFIFTCC
  • 5. L12A03898|    From 1 To 24 E-value: 0.00000001 Score: 50.4
        GNGVIKTVSHECKMNTWQFLFTCC

Structure

  •   Domains
  •   1  Name:Lantibiotic_typ-A    Interpro Link:IPR007682
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Veau G.,Ladire M.,Joubert P.,Gomez A.,Marcille F.,
  •   Title:Distribution of genes encoding the trypsin-dependent lantibiotic ruminococcin A among bacteria isolated from human fecal microbiota.
  •   Journal:Appl. Environ. Microbiol., 2002, 68, 3424-3431  [MEDLINE:22083478]

Comments

  •   Comments

    •     No comments found on LAMP database



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