Record in detail


General Info

  • lamp_id:L01A002465
  • Name:M1H12_BOMMX
  • FullName:Maximins 1/H12
  • Source:Bombina maxima
  • Mass:1961.4 Da
  • Sequence Length:20 aa
  • Isoelectric Point:9.69
  • Activity:Antibacterial, Antifungal
  • Sequence
        LLGPVLGLVSNALGGLLKNI
  • Function:Maximin-1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity. It possess a significant cytotoxicity against tumor cell lines. It does not possess a significant anti-HIV activity. It shows high spermicidal activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002465    From 1 To 20 E-value: 0.0001 Score: 36.6
        LLGPVLGLVSNALGGLLKNI
  • 2. L01A003306    From 1 To 20 E-value: 0.0002 Score: 36.2
        ILGPVLGLVSNALGGLLKNI
  • 3. L01A003334    From 1 To 20 E-value: 0.0004 Score: 34.7
        ILGPVLGLVSNALGGLLKNL
  • 4. L13A024824    From 1 To 20 E-value: 0.0005 Score: 34.7
        IMGPVLGLVSNALGGLLKNL
  • 5. L13A020611    From 1 To 20 E-value: 0.0009 Score: 33.9
        ILGPVLGLVSNALGGLIKRI

Structure

  •   Domains
  •   1  Name:Bombinin    Interpro Link:IPR007962
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Liu H.,Liu G.-J.,Shen J.-H.,Zheng Y.-T.,Lai R.,
  •   Title:Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
  •   Journal:Peptides, 2002, 23, 427-435  [MEDLINE:21826911]
  •   [2]  Zhang Y.,Li S.,Lai R.,Li Y.,Lee W.-H.,
  •   Title:Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
  •   Journal:Eur. J. Immunol., 2005, 35, 1220-1229  [PubMed:15770703]

Comments

  •   Comments

    •     No comments found on LAMP database



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