Record in detail

lamp_id:L01A002661
Name:DEFN_HELVI
FullName:Defensin heliomicin
Source:Heliothis virescens
Mass:4790.3 Da
Sequence Length:44 aa
Isoelectric Point:7.76
Activity:Antifungal
Sequence
DKLIGSCVWGAVNYTSDCNGECKRRGYKGGHCGSFANVNCWCET
Function:This peptide has potent anti-fungal activity. Has no activity against Gram-negative and Gram-positive bacteria.

Top similar AMPs on LAMP
1. L01A002661 From 1 To 44 E-value: 4e-21 Score: 92
DKLIGSCVWGAVNYTSDCNGECKRRGYKGGHCGSFANVNCWCET
2. L11A004599 From 1 To 44 E-value: 1e-20 Score: 90.1
DKLIGSCVWGAVNYTSDCNGECKRRGYKGGHCGSFANVNCWCRT
3. L13A018520 From 1 To 44 E-value: 1e-20 Score: 89.7
DKLIGSCVWGAVNYTSDCNGECKRRGYKGGYCGSFANVNCWCET
4. L01A000663 From 1 To 44 E-value: 3e-20 Score: 89
DKLIGSCVWGAVNYTSNCNAECKRRGYKGGHCGSFANVNCWCET
5. L11A004597 From 1 To 44 E-value: 4e-20 Score: 88.6
DKLIGSCVWGAVNYTSDCAAECKRRGYKGGHCGSFANVNCWCET

Antibacterial Activities
1 Target: N. crassa MIC: 0.48 μg/ml (0.100202 μM)
2 Target: F. culmorum MIC: 0.96 μg/ml (0.200405 μM)
3 Target: F. oxysporum MIC: 7.19 μg/ml (1.50095 μM)
4 Target: N. haematococca MIC: 1.92 μg/ml (0.40081 μM)
5 Target: A. fumigatus MIC: 28.74 μg/ml (5.99962 μM)
6 Target: T. viride MIC: 7.19 μg/ml (1.50095 μM)
7 Target: C. albicans MIC: 11.98 μg/ml (2.50089 μM)
8 Target: C. neoformans MIC: 11.98 μg/ml (2.50089 μM)

Reference
[1] Bushey D.,Brookhart G.,Uttenweiler-Joseph S.,Ades S.,Lamberty M.,
Title:Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity.
Journal:J. Biol. Chem., 1999, 274, 9320-9326 [MEDLINE:99194775]
[2] Hetru C.,Tassin-Moindrot S.,Landon C.,Caille A.,Lamberty M.,
Title:Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities.
Journal:Biochemistry, 2001, 40, 11995-12003 [MEDLINE:21464431]