Record in detail


General Info

  • lamp_id:L01A002678
  • Name:DCRLN_OREDC
  • FullName:Decoralin
  • Source:Oreumenes decoratus
  • Mass:1256.6 Da
  • Sequence Length:11 aa
  • Isoelectric Point:11.66
  • Activity:Antibacterial, Antifungal
  • Sequence
        SLLSLIRKLIT
  • Function:Linear cationic alpha-helical peptide that acts as antimicrobial peptide. At high concentrations exhibits activity in stimulating degranulation from rat peritoneal mast cells. Has antibacterial activity against the Gram-positive bacteria S.aureus CCT 6538 (MIC=40 uM), S.saprophyticus (MIC=40 um), B.subtilis CCT 2471 (MIC=40 uM), and B.thuringiensis (MIC=40 uM), and against the Gram-negative bacteria E.coli ATCC 25922 (MIC=80), E.coli CCT 1371 (MIC=160), K.pneumonia ATCC 13883 (MIC=80), and A.faecalis ATCC 8750 (MIC=40). Has antifungal activity against C.albicans (MIC=40 uM). Inhibits the growth of L.major promastigotes in vitro with an IC(50) of 72 uM. Has very weak hemolytic activity towards human and mouse erythrocytes.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002678    From 1 To 11 E-value: 3 Score: 21.2
        SLLSLIRKLIT
  • 2. L11A011551    From 1 To 11 E-value: 5.5 Score: 20.4
        SFLSLIRKLIT
  • 3. L11A010683    From 1 To 11 E-value: 6.9 Score: 20
        SLLSLIRKLLT
  • 4. L02A000723    From 1 To 11 E-value: 6.9 Score: 20
        SLLSLLRKLIT
  • 5. L11A011552    From 1 To 11 E-value: 7.4 Score: 20
        SLLSLFRKLIT

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S.aureus CCT 6538  MIC:  50.26 μg/ml  (39.9968 μM)  
  •   2  Target:  S.saprophyticus  MIC:  50.26 μg/ml  (39.9968 μM)  
  •   3  Target:  B.subtilis CCT 2471  MIC:  50.26 μg/ml  (39.9968 μM)  
  •   4  Target:  B.thuringiensis  MIC:  50.26 μg/ml  (39.9968 μM)  
  •   5  Target:  E.coli ATCC 25922  MIC:  100.53 μg/ml  (80.0016 μM)  
  •   6  Target:  E.coli CCT 1371  MIC:  201.06 μg/ml  (160.003 μM)  
  •   7  Target:  K.pneumonia ATCC 13883  MIC:  100.53 μg/ml  (80.0016 μM)  
  •   8  Target:  A.faecalis ATCC 8750  MIC:  50.26 μg/ml  (39.9968 μM)  
  •   9  Target:  C.albicans  MIC:  50.26 μg/ml  (39.9968 μM)  
  •   10  Target:  L.major promastigotes  IC50:  90.48 μg/ml  (72.0038 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Fontana R.,Dos Santos Cabrera M.P.,Oliveira J.S.,Rangel M.,Konno K.,
  •   Title:Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus.
  •   Journal:Peptides, 2007, 28, 2320-2327  [PubMed:17981364]

Comments

  •   Comments

    •     No comments found on LAMP database



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