Record in detail

lamp_id:L01A002712
Name:DEF6_HUMAN
FullName:Defensin-6
Source:Homo sapiens
Mass:3714.2 Da
Sequence Length:32 aa
Isoelectric Point:8.12
Activity:Antibacterial
Sequence
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
Function:Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.

Top similar AMPs on LAMP
1. L01A003418 From 4 To 35 E-value: 0.00000000000009 Score: 67.4
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
2. L01A002712 From 1 To 32 E-value: 0.0000000000001 Score: 67
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
3. L13A011306 From 1 To 31 E-value: 0.0000000000004 Score: 65.1
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCC
4. L12A00192| From 1 To 32 E-value: 0.0000000000007 Score: 64.3
AFTCHCRRSCYSTEYSYGTCTVMGINWRFCCL
5. L12A09221| From 63 To 93 E-value: 0.001 Score: 33.9
IICHCRRLLCLSSEHLSGICTIKGVRYPFCC

Reference
[1] Bevins C.L.,Jones D.E.,
Title:Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel.
Journal:FEBS Lett., 1993, 315, 187-192 [MEDLINE:93114459]
[2] Deberardinis R.J.,Russell J.P.,Salzman N.,Harris A.,Mallow E.B.,
Title:Human enteric defensins. Gene structure and developmental expression.
Journal:J. Biol. Chem., 1996, 271, 4038-4045 [MEDLINE:96223969]
[3]
Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Journal:Genome Res., 2004, 14, 2121-2127 [PubMed:15489334]
[4] Lehrer R.I.,Lu W.,Wu Z.,Ericksen B.,
Title:Antibacterial activity and specificity of the six human alpha-defensins.
Journal:Antimicrob. Agents Chemother., 2005, 49, 269-275 [PubMed:15616305]
[5] Lu W.,Yang D.,Tucker K.,Wu Z.,Szyk A.,
Title:Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
Journal:Protein Sci., 2006, 15, 2749-2760 [PubMed:17088326]