Record in detail

General Info

lamp_id:L01A002758
Name:ETC76_ENTSX
FullName:Enterocin E-760
Source:Enterococcus sp.
Mass:6179.9 Da
Sequence Length:62 aa
Isoelectric Point:8.91
Activity:Antibacterial
Sequence
NRWYCNSAAGGVGGAAVCGLAGYVGEAKENIAGEVRKGWGMAGGFTHNKACKSFPGSGWASG
Function:Bacteriocin active against the Gram-negative bacteria S.enteritidis, S.choleraesuis, S.typhimurium, S.gallinarum, E.coli O157:H7, Y.enterocolitica, C.freundii, K.pneumoniae, S.dysentriae, P.aeruginosa, P.mirabilis, M.morganii, C.jejuni and 20 other Campylobacter isolates, and the Gram-positive bacteria S.aureus, S.epidermidis and L.monocytogenes.

Cross-Linking

Cross-linking
1 Database:CAMP CAMPSQ797
2 Database:DBAASP 1780
3 Database:dbAMP dbAMP_09813
4 Database:DRAMP DRAMP00136
5 Database:Uniprot P85147
6 Database:BAC BAC174

Top similar AMPs

Top similar AMPs on LAMP
1. L01A002758 From 1 To 62 E-value: 3e-30 Score: 122
NRWYCNSAAGGVGGAAVCGLAGYVGEAKENIAGEVRKGWGMAGGFTHNKACKSFPGSGWASG
2. L02A000807 From 1 To 62 E-value: 4e-24 Score: 101
NRWYCNSAAGGVGGAAGCVLAGYVGEAKENIAGEVRKGWGMAGGFTHNKACKSFPGSGWASG
3. L13A011789 From 1 To 50 E-value: 4e-23 Score: 98.6
NRWYCNSAAGGVGGAAVCGLAGYVGEAKENIAGEVRKGWGMAGGFTHNKA
4. L13A026328 From 1 To 50 E-value: 4e-17 Score: 78.6
NRWYCNSAAGGVGGAAGCVLAGYVGEAKENIAGEVRKGWGMAGGFTHNKA
5. L12A09065| From 48 To 68 E-value: 0.19 Score: 26.2
GEAKENIAGIVISGWASGLAG

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: S. enterica serovar Enteritidis 1 MIC: 0.2 μg/ml (0.032363 μM)
2 Target: S. enterica serovar Enteritidis 4 MIC: 0.4 μg/ml (0.064726 μM)
3 Target: S. enterica serovar Enteritidis 204 MIC: 0.2 μg/ml (0.032363 μM)
4 Target: S. enterica serovar Enteritidis 237 MIC: 0.2 μg/ml (0.032363 μM)
5 Target: S. enterica serovar Choleraesuis 434/4 MIC: 0.4 μg/ml (0.064726 μM)
6 Target: S. enterica serovar Choleraesuis 370 MIC: 0.4 μg/ml (0.064726 μM)
7 Target: S. enterica serovar Typhimurium 383/60 MIC: 0.4 μg/ml (0.064726 μM)
8 Target: S. enterica serovar Typhimurium 320 MIC: 0.2 μg/ml (0.032363 μM)
9 Target: S. enterica serovar Gallinarum biovar Pullorum MIC: 0.4 μg/ml (0.064726 μM)
10 Target: Escherichia coli HB101 MIC: 0.1 μg/ml (0.0161815 μM)
11 Target: E. coli C600 MIC: 0.1 μg/ml (0.0161815 μM)
12 Target: E. coli O157:H7 Y-63 MIC: 1.6 μg/ml (0.258904 μM)
13 Target: E. coli O157:H7 G-3 MIC: 1.6 μg/ml (0.258904 μM)
14 Target: E. coli O157:H7 OD-3 MIC: 1.6 μg/ml (0.258904 μM)
15 Target: E. coli O157:H7 T-39 MIC: 1.6 μg/ml (0.258904 μM)
16 Target: Yersinia enterocolitica 03 MIC: 0.1 μg/ml (0.0161815 μM)
17 Target: Y. enterocolitica 09 MIC: 0.1 μg/ml (0.0161815 μM)
18 Target: Y. enterocolitica 04 MIC: 0.1 μg/ml (0.0161815 μM)
19 Target: Y. pseudotuberculosis ser 4 MIC: 3.2 μg/ml (0.517808 μM)
20 Target: Y. pseudotuberculosis 14 MIC: 3.2 μg/ml (0.517808 μM)
21 Target: Citrobacter freundii MIC: 1.6 μg/ml (0.258904 μM)
22 Target: Klebsiella pneumoniae MIC: 3.2 μg/ml (0.517808 μM)
23 Target: Shigella dysenteriae MIC: 0.1 μg/ml (0.0161815 μM)
24 Target: C. jejuni L4 MIC: 0.1 μg/ml (0.0161815 μM)
25 Target: Staphylococcus aureus MIC: 1.6 μg/ml (0.258904 μM)
26 Target: Staphylococcus epidermidis MIC: 1.6 μg/ml (0.258904 μM)
27 Target: Listeria monocytogenes 9-72 MIC: 0.1 μg/ml (0.0161815 μM)

Toxicity

Toxicity

Reference

Reference
[1] Mitsevich E.V.,Perelygin V.V.,Eruslanov B.V.,Svetoch E.A.,Line J.E.,
Title:Isolation and purification of enterocin E-760 with broad antimicrobial activity against Gram-positive and Gram-negative bacteria.
Journal:Antimicrob. Agents Chemother., 2008, 52, 1094-1100 [PubMed:18086839]

Comments

Comments