Record in detail

General Info

lamp_id:L01A002768
Name:OCE4_LEPOE
FullName:Ocellatin-4
Source:Leptodactylus ocellatus
Mass:2275.7 Da
Sequence Length:21 aa
Isoelectric Point:6.34
Activity:Antibacterial
Sequence
GLLDFVTGVGKDIFAQLIKQI
Function:Has hemolytic activity against human erythrocytes (HC50=14.3uM). Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=64uM) and the Gram-negative bacterium E.coli ATCC 25922 (MIC=64uM).

Cross-Linking

Cross-linking
1 Database:APD 894
2 Database:CAMP CAMPSQ806
3 Database:DBAASP 4115
4 Database:dbAMP dbAMP_03498
5 Database:DRAMP DRAMP01174
6 Database:SATPdb satpdb19755
7 Database:Uniprot P85090

Top similar AMPs

Top similar AMPs on LAMP
1. L01A002768 From 1 To 21 E-value: 0.000003 Score: 42
GLLDFVTGVGKDIFAQLIKQI
2. L11A012406 From 2 To 21 E-value: 0.099 Score: 26.9
LLKFVTKVGKAIFKALIKAI
3. L02A001404 From 1 To 21 E-value: 0.31 Score: 25.4
GVLDILTGAGKDLLAHALSKL
4. L11A004384 From 1 To 21 E-value: 0.46 Score: 24.6
GILDTVKGVAKDVAAHLLNMV
5. L12A01002| From 14 To 34 E-value: 0.46 Score: 24.6
GILDLVTHVAKNLAAQLLDKL

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 145.645 μg/ml (64 μM)
2 Target: S. aureus MIC: 145.645 μg/ml (64 μM)

Toxicity

Toxicity

Reference

Reference
[1] Sousa M.V.,Sebben A.,Perales J.,Chapeaurouge A.,Nascimento A.C.C.,
Title:Purification, characterization and homology analysis of ocellatin 4, a cytolytic peptide from the skin secretion of the frog Leptodactylus ocellatus.
Journal:Toxicon, 2007, 50, 1095-1104 [PubMed:17884127]

Comments

Comments