Record in detail


General Info

  • lamp_id:L01A002804
  • Name:MCBA_ECOLX
  • FullName:Bacteriocin microcin B17
  • Source:Escherichia coli
  • Mass:3255.4 Da
  • Sequence Length:43 aa
  • Isoelectric Point:7.12
  • Activity:Antimicrobial
  • Sequence
        VGIGGGGGGGGGGSCGGQGGGCGGCSNGCSGGNGGSGGSGSHI
  • Function:This glycine-rich peptide antibiotic inhibits DNA replication in many enteric bacteria, that leads to induction of the SOS repair system, massive DNA degradation and cell death. B17 inhibits type II topoisomerase by trapping an enzyme - DNA cleavable complex.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002804    From 1 To 43 E-value: 0.00000000002 Score: 59.7
        VGIGGGGGGGGGGSCGGQGGGCGGCSNGCSGGNGGSGGSGSHI
  • 2. L13A025911    From 1 To 42 E-value: 0.00000000009 Score: 57.4
        VGIGGGGGGGGGGSCGGQGGGCGGCSNGCSGGNGGSGGSGSH

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Kolter R.,Moreno F.,Furlong D.,Herrero M.,Davagnino J.,
  •   Title:The DNA replication inhibitor microcin B17 is a forty-three-amino-acid protein containing sixty percent glycine.
  •   Journal:Proteins, 1986, 1, 230-238  [MEDLINE:88217867]
  •   [2]  Kolter R.,Moreno F.,Han Z.,Conell N.,
  •   Title:An E. coli promoter induced by the cessation of growth.
  •   Journal:Mol. Microbiol., 1987, 1, 195-201  [MEDLINE:88216163]
  •   [3]  Kolter R.,Moreno F.,Genilloud O.,
  •   Title:DNA sequence, products, and transcriptional pattern of the genes involved in production of the DNA replication inhibitor microcin B17.
  •   Journal:J. Bacteriol., 1989, 171, 1126-1135  [MEDLINE:89123111]
  •   [4]  Moreno F.,del Castillo I.,Hernandez-Chico C.,Vizan J.L.,
  •   Title:The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase.
  •   Journal:EMBO J., 1991, 10, 467-476  [MEDLINE:91122055]
  •   [5]  Warner P.,Vivas E.,Koerdel J.,Lee J.,Yorgey P.,
  •   Title:Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 1994, 91, 4519-4523  [MEDLINE:94240167]
  •   [6]  Walsh C.T.,Baleja J.D.,Kim S.,Roy R.S.,
  •   Title:Role of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26.
  •   Journal:Chem. Biol., 1998, 5, 217-228  [MEDLINE:98213789]

Comments

  •   Comments

    •     No comments found on LAMP database



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