Record in detail


General Info

  • lamp_id:L01A002812
  • Name:FALX1_LITFA
  • FullName:Preprofallaxidin-1
  • Source:Litoria fallax
  • Mass:2194.7 Da
  • Sequence Length:21 aa
  • Isoelectric Point:9.69
  • Activity:Antibacterial
  • Sequence
        GLLSFLPKVIGVIGHLIHPPS
  • Function:Fallaxidin-4.1 shows antibacterial activity against the Gram-positive bacteria L.lactis (MIC=12 uM), M.luteus (MIC=100 uM), S.epidermidis (MIC=100 uM) and S.uberis (MIC=50 uM). No anti-bacterial activity against the Gram-positive bacteria B.cereus, E.faecalis, L.innocua, S.aureus, or the Gram-negative bacteria E.cloacae and E.coli. Inhibits the formation of NO by neuronal nitric oxide synthase with an IC(50) of 13.3 uM.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06442|    From 47 To 67 E-value: 0.0000004 Score: 45.1
        GLLSFLPKVIGVIGHLIHPPS
  • 2. L01A002812    From 1 To 21 E-value: 0.000003 Score: 42
        GLLSFLPKVIGVIGHLIHPPS
  • 3. L13A023647    From 1 To 21 E-value: 0.00008 Score: 37.4
        GLFSFLPKVIGVIGPLIHPPS
  • 4. L01A001509    From 30 To 46 E-value: 2.5 Score: 22.3
        FLRFIGSVIHGIGHLVH
  • 5. L01A000254    From 1 To 16 E-value: 8.3 Score: 20.8
        GLFDIAKKVIGVIGSL

Structure

  •   Domains
  •   1  Name:Brevinin    Interpro Link:IPR004275
  •   2  Name:Dermaseptin_precursor    Interpro Link:IPR016322
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  L.lactis  MIC:  26.34 μg/ml  (12.0016 μM)  
  •   2  Target:  M.luteus  MIC:  219.47 μg/ml  (100 μM)  
  •   3  Target:  S.epidermidis  MIC:  219.47 μg/ml  (100 μM)  
  •   4  Target:  S.uberis  MIC:  109.74 μg/ml  (50.0023 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Surinya-Johnson K.H.,Musgrave I.F.,Bilusich D.,Bowie J.H.,Jackway R.J.,
  •   Title:The fallaxidin peptides from the skin secretion of the eastern dwarf tree frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins.
  •   Journal:Rapid Commun. Mass Spectrom., 2008, 22, 3207-3216  [PubMed:18803332]

Comments

  •   Comments

    •     No comments found on LAMP database



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