Record in detail


General Info

  • lamp_id:L01A002816
  • Name:MEP_MELAF
  • FullName:Melectin
  • Source:Melecta albifrons
  • Mass:2040.6 Da
  • Sequence Length:18 aa
  • Isoelectric Point:11.28
  • Activity:Antibacterial
  • Sequence
        GFLSILKKVLPKVMAHMK
  • Function:Antimicrobial activity against the Gram-positive bacteria B.subtilis (MIC=0.8 uM) and S.aureus (MIC=6.8 uM), and against the Gram-negative bacteria E.coli (MIC=2.0 uM) and P.aeruginosa (MIC=18.5 uM). Stimulates degranulation from rat peritoneal mast cells with an EC(50) of 19.4 uM. Has very weak hemolytic activity towards rat erythrocytes.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002816    From 1 To 18 E-value: 0.00009 Score: 37
        GFLSILKKVLPKVMAHMK
  • 2. L11A008308    From 1 To 18 E-value: 0.00009 Score: 37
        GFLSILKKVLPKVMAHMK
  • 3. L11A005678    From 1 To 18 E-value: 0.0004 Score: 35
        GFLSILKKVLPKVXAHMK
  • 4. L11A005676    From 1 To 18 E-value: 0.0004 Score: 35
        GFLSILKKVLPKVMAHXK
  • 5. L11A008325    From 1 To 18 E-value: 0.0004 Score: 35
        GFLSILKKVLPKVMAHXK

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Bednarova L.,Voburka Z.,Cvacka J.,Hovorka O.,Cerovsky V.,
  •   Title:Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons.
  •   Journal:ChemBioChem, 2008, 9, 2815-2821  [PubMed:18942691]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: