Record in detail

lamp_id:L01A002833
Name:DEFI_PHLDU
FullName:Defensin
Source:Phlebotomus duboscqi
Mass:4101.7 Da
Sequence Length:40 aa
Isoelectric Point:8.39
Activity:Antibacterial, Antifungal
Sequence
ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR
Function:Has antiparasitic activity against promastigote forms of L.major, and antibacterial activity against Gram-positive bacterium S.aureus. Has antifungal activity against the yeasts C.albicans and S.cerevisiae, but not C.glabrata. Has antifungal activity against filamentous fungi A.fumigatus, F.culmorum, F.oxysporum, N.crassa, T.viride and T.mentagrophytes, but not B.bassiana.

Top similar AMPs on LAMP
1. L12A09191| From 59 To 98 E-value: 3e-19 Score: 85.1
ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR
2. L01A002833 From 1 To 40 E-value: 9e-18 Score: 80.5
ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR
3. L03A000168 From 59 To 97 E-value: 0.0000000000001 Score: 66.6
ATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCR
4. L03A000348 From 57 To 94 E-value: 0.0000000000006 Score: 64.3
ATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVC
5. L01A000505 From 1 To 39 E-value: 0.0000000000009 Score: 63.9
ATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCR

Antibacterial Activities
1 Target: S. aureus MIC: 3.2 μg/ml (0.780164 μM)
2 Target: Aspergillus fumigatus MIC: 51.27 μg/ml (12.4997 μM)
3 Target: F. culmorum MIC: 6.4 μg/ml (1.56033 μM)
4 Target: F. oxysporum MIC: 12.8 μg/ml (3.12066 μM)
5 Target: Neurospora crassa MIC: 25.64 μg/ml (6.25107 μM)
6 Target: T. viride MIC: 12.8 μg/ml (3.12066 μM)
7 Target: Trichophyton mentagrophytes MIC: 102.54 μg/ml (24.9994 μM)
8 Target: Candida albicans MIC: 25.64 μg/ml (6.25107 μM)
9 Target: S. cerevisiae MIC: 102.54 μg/ml (24.9994 μM)
10 Target: L. major promastigote forms IC50: 278.92 μg/ml (68.0011 μM)

Reference
[1] Sigutova L.,Ursic R.,Volf P.,Lowenberger C.,Boulanger N.,
Title:Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major.
Journal:Infect. Immun., 2004, 72, 7140-7146 [PubMed:15557638]