Record in detail

General Info

lamp_id:L01A002841
Name:DMS4_PACDA
FullName:Dermaseptin PD-3-6
Source:Pachymedusa dacnicolor
Mass:2127.4 Da
Sequence Length:23 aa
Isoelectric Point:3.75
Activity:Antibacterial
Sequence
GVVTDLLNTAGGLLGNLVGSLSG
Function:Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Cross-Linking

Cross-linking
1 Database:APD 1385
2 Database:CAMP CAMPSQ1525
3 Database:DBAASP 4184
4 Database:dbAMP dbAMP_04306
5 Database:DRAMP DRAMP01695
6 Database:SATPdb satpdb21886
7 Database:Uniprot O93454

Top similar AMPs

Top similar AMPs on LAMP
1. L03A000079 From 46 To 68 E-value: 0.0000007 Score: 44.3
GVVTDLLNTAGGLLGNLVGSLSG
2. L01A002841 From 1 To 23 E-value: 0.000005 Score: 41.6
GVVTDLLNTAGGLLGNLVGSLSG
3. L02A000740 From 1 To 23 E-value: 0.00005 Score: 38.1
GVVTDLLKTAGKLLGNLVGSLSG
4. L02A000739 From 1 To 23 E-value: 0.0001 Score: 36.6
GVVTDLLKTAGKLLGNLFGSLSG
5. L11A004187 From 1 To 23 E-value: 0.001 Score: 33.9
GLVTGLLNTAGGLLGDLFGSLSG

Structure

Domains
1 Name:Brevinin Interpro Link:IPR004275
2 Name:Dermaseptin_precursor Interpro Link:IPR016322

Structures

Activity

Antibacterial Activities
1 Target: S. aureus MIC: 531.85 μg/ml (250 μM)

Toxicity

Toxicity

Reference

Reference
[1] Wechselberger C.
Title:Cloning of cDNAs encoding new peptides of the dermaseptin-family.
Journal:Biochim. Biophys. Acta, 1998, 1388, 279-283 [MEDLINE:98449786]

Comments

Comments