Record in detail

lamp_id:L01A002853
Name:HEPC_MOUSE
FullName:Hepcidin
Source:Mus musculus
Mass:2762.3 Da
Sequence Length:25 aa
Isoelectric Point:7.6
Activity:Antimicrobial
Sequence
DTNFPICIFCCKCCNNSQCGICCKT
Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.

Top similar AMPs on LAMP
1. L03A000101 From 59 To 83 E-value: 0.0000000004 Score: 55.1
DTNFPICIFCCKCCNNSQCGICCKT
2. L01A002853 From 1 To 25 E-value: 0.00000001 Score: 50.1
DTNFPICIFCCKCCNNSQCGICCKT
3. L12A06338| From 59 To 83 E-value: 0.0000003 Score: 45.4
DTHFPICLFCCGCCNKSKCGICCKT
4. L12A06326| From 59 To 83 E-value: 0.0000003 Score: 45.4
DTHFPICIFCCGCCHKSKCGICCKT
5. L12A11449| From 30 To 54 E-value: 0.0000003 Score: 45.4
DTHFPICIFCCGCCHKSKCGICCKT

Reference
[1] Turlin B.,Leroyer P.,Courselaud B.,Ilyin G.,Pigeon C.,
Title:A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.
Journal:J. Biol. Chem., 2001, 276, 7811-7819 [MEDLINE:21269329]
[2] Grandchamp B.,Beaumont C.,Devaux I.,Bennoun M.,Nicolas G.,
Title:Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice.
Journal:Proc. Natl. Acad. Sci. U.S.A., 2001, 98, 8780-8785 [MEDLINE:21353006]
[3] Alizadeh M.,Pigeon C.,Troadec M.-B.,Courselaud B.,Ilyin G.,
Title:Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload.
Journal:FEBS Lett., 2003, 542, 22-26 [MEDLINE:22615571]
[4]
Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Journal:Genome Res., 2004, 14, 2121-2127 [PubMed:15489334]