Record in detail

lamp_id:L01A002863
Name:H6_ONCMY
FullName:Non-histone chromosomal protein H6
Source:Oncorhynchus mykiss
Mass:6642.6 Da
Sequence Length:66 aa
Isoelectric Point:11.48
Activity:Antibacterial
Sequence
PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG
Function:Non-histone protein that probably binds to the inner side of nucleosomal DNA, altering the association between the DNA and the nucleosome octamer.

Top similar AMPs on LAMP
1. L12A08907| From 2 To 67 E-value: 1e-28 Score: 116
PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG
2. L01A002863 From 1 To 66 E-value: 2e-28 Score: 116
PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG
3. L02A000410 From 1 To 66 E-value: 2e-28 Score: 116
PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAG
4. L13A010420 From 1 To 50 E-value: 4e-20 Score: 88.6
PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENG
5. L02A000335 From 1 To 13 E-value: 0.055 Score: 28.1
PKRKSATKGDEPA

Antibacterial Activities
1 Target: A. viridans MIC: 0.06 μg/ml (0.00903261 μM)
2 Target: B. subtilis MIC: 0.25 μg/ml (0.0376359 μM)
3 Target: M. luteus MIC: 0.12 μg/ml (0.0180652 μM)
4 Target: P. citreus MIC: 0.06 μg/ml (0.00903261 μM)
5 Target: A. salmonicida 004 MIC: 3.32 μg/ml (0.499804 μM)
6 Target: E. coli MIC: 0.25 μg/ml (0.0376359 μM)
7 Target: L. anguillarum MIC: 0.25 μg/ml (0.0376359 μM)

Reference
[1] Dixon G.H.,Wong N.C.W.,Watson D.C.,
Title:The complete amino-acid sequence of a trout-testis non-histone protein, H6, localized in a subset of nucleosomes and its similarity to calf-thymus non-histone proteins HMG-14 and HMG-17.
Journal:Eur. J. Biochem., 1979, 95, 193-202 [MEDLINE:79213375]
[2] Smith V.J.,Kemp G.D.,Saint N.,Fernandes J.M.O.,
Title:Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss.
Journal:Biochem. J., 2003, 373, 621-628 [MEDLINE:22726124]