Record in detail
General Info
- lamp_id:L01A002867
- Name:PG1_PIG
- FullName:Protegrin-1
- Source:Sus scrofa
- Mass:2160.6 Da
- Sequence Length:18 aa
- Isoelectric Point:10.92
- Activity:Antibacterial
- Sequence
RGGRLCYCRRRFCVCVGR - Function:Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.
Cross-Linking
- Cross-linking
- 1 Database:APD 195
- 2 Database:CAMP CAMPSQ858
- 3 Database:DBAASP 672
- 4 Database:dbAMP dbAMP_10433
- 5 Database:DRAMP DRAMP02970
- 6 Database:SATPdb satpdb13787
- 7 Database:Uniprot P32194
- 8 Database:AMD PG1_PIG
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L12A10434| From 1 To 18 E-value: 0.0002 Score: 36.2
RGGRLCYCRRRFCVCVGR - 2. L01A002867 From 1 To 18 E-value: 0.0002 Score: 36.2
RGGRLCYCRRRFCVCVGR - 3. L01A002668 From 1 To 18 E-value: 0.0005 Score: 34.3
RGGRLCYCRPRFCVCVGR - 4. L03A000324 From 1 To 18 E-value: 0.0005 Score: 34.3
RGGRLCYCRPRFCVCVGR - 5. L11A010042 From 9 To 24 E-value: 0.0008 Score: 33.9
RGGRLCYCRRRFCVCV
Activity
- Antibacterial Activities
- 1 Target: E. coli MIC: 64 μg/ml (29.6214 μM)
- 2 Target: S. aureus MIC: 64 μg/ml (29.6214 μM)
- 3 Target: S. epiderrnidis MIC: 2 μg/ml (0.925669 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Egorov T.A.,Chernushevich I.V.,Abdalla K.O.M.A.,Shevchenko A.A.,Mirgorodskaya O.A.,
- Title:Primary structure of three cationic peptides from porcine neutrophils. Sequence determination by the combined usage of electrospray ionization mass spectrometry and Edman degradation.
- Journal:FEBS Lett., 1993, 330, 339-342 [MEDLINE:93387466]
- [2] Aleshina G.M.,Shevchenko A.A.,Panyutich E.A.,Harwig S.S.L.,Kokryakov V.N.,
- Title:Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.
- Journal:FEBS Lett., 1993, 327, 231-236 [MEDLINE:93327946]
- [3] Lehrer R.I.,Liu L.,Zhao C.,
- Title:Identification of a new member of the protegrin family by cDNA cloning.
- Journal:FEBS Lett., 1994, 346, 285-288 [MEDLINE:94283613]
- [4] Lehrer R.I.,Ganz T.,Zhao C.,
- Title:The structure of porcine protegrin genes.
- Journal:FEBS Lett., 1995, 368, 197-202 [MEDLINE:95354835]
- [5] Eisenberg D.,Lehrer R.I.,Harwig S.S.,Dieckmann T.,Fahrner R.L.,
- Title:Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes.
- Journal:Chem. Biol., 1996, 3, 543-550 [MEDLINE:97113279]
- [6] Despaux E.,Chiche L.,Roumestand C.,Mangoni M.,Aumelase A.,
- Title:Synthesis and solution structure of the antimicrobial peptide protegrin-1.
- Journal:Eur. J. Biochem., 1996, 237, 575-583 [MEDLINE:96235220]
Comments
- Comments
No comments found on LAMP database