Record in detail


General Info

  • lamp_id:L01A002867
  • Name:PG1_PIG
  • FullName:Protegrin-1
  • Source:Sus scrofa
  • Mass:2160.6 Da
  • Sequence Length:18 aa
  • Isoelectric Point:10.92
  • Activity:Antibacterial
  • Sequence
        RGGRLCYCRRRFCVCVGR
  • Function:Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A10434|    From 1 To 18 E-value: 0.0002 Score: 36.2
        RGGRLCYCRRRFCVCVGR
  • 2. L01A002867    From 1 To 18 E-value: 0.0002 Score: 36.2
        RGGRLCYCRRRFCVCVGR
  • 3. L01A002668    From 1 To 18 E-value: 0.0005 Score: 34.3
        RGGRLCYCRPRFCVCVGR
  • 4. L03A000324    From 1 To 18 E-value: 0.0005 Score: 34.3
        RGGRLCYCRPRFCVCVGR
  • 5. L11A010042    From 9 To 24 E-value: 0.0008 Score: 33.9
        RGGRLCYCRRRFCVCV

Structure

  •   Domains
  •   1  Name:Cathelicidin    Interpro Link:IPR001894
  •   2  Name:Cathelicidin_CS    Interpro Link:IPR018216
  •   Structures
  •   1
    PDB:1PG1

    Method:NMR
    Chains:A=131-148
  •   2
    PDB:1ZY6

    Method:NMR
    Chains:A/B=131-148

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  64 μg/ml  (29.6214 μM)  
  •   2  Target:  S. aureus  MIC:  64 μg/ml  (29.6214 μM)  
  •   3  Target:  S. epiderrnidis  MIC:  2 μg/ml  (0.925669 μM)  

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Egorov T.A.,Chernushevich I.V.,Abdalla K.O.M.A.,Shevchenko A.A.,Mirgorodskaya O.A.,
  •   Title:Primary structure of three cationic peptides from porcine neutrophils. Sequence determination by the combined usage of electrospray ionization mass spectrometry and Edman degradation.
  •   Journal:FEBS Lett., 1993, 330, 339-342  [MEDLINE:93387466]
  •   [2]  Aleshina G.M.,Shevchenko A.A.,Panyutich E.A.,Harwig S.S.L.,Kokryakov V.N.,
  •   Title:Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.
  •   Journal:FEBS Lett., 1993, 327, 231-236  [MEDLINE:93327946]
  •   [3]  Lehrer R.I.,Liu L.,Zhao C.,
  •   Title:Identification of a new member of the protegrin family by cDNA cloning.
  •   Journal:FEBS Lett., 1994, 346, 285-288  [MEDLINE:94283613]
  •   [4]  Lehrer R.I.,Ganz T.,Zhao C.,
  •   Title:The structure of porcine protegrin genes.
  •   Journal:FEBS Lett., 1995, 368, 197-202  [MEDLINE:95354835]
  •   [5]  Eisenberg D.,Lehrer R.I.,Harwig S.S.,Dieckmann T.,Fahrner R.L.,
  •   Title:Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes.
  •   Journal:Chem. Biol., 1996, 3, 543-550  [MEDLINE:97113279]
  •   [6]  Despaux E.,Chiche L.,Roumestand C.,Mangoni M.,Aumelase A.,
  •   Title:Synthesis and solution structure of the antimicrobial peptide protegrin-1.
  •   Journal:Eur. J. Biochem., 1996, 237, 575-583  [MEDLINE:96235220]

Comments

  •   Comments

  •     No comments found on LAMP database



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