Record in detail


General Info

  • lamp_id:L01A002869
  • Name:PG3_PIG
  • FullName:Protegrin-3
  • Source:Sus scrofa
  • Mass:2061.5 Da
  • Sequence Length:18 aa
  • Isoelectric Point:9.72
  • Activity:Antibacterial, Antifungal
  • Sequence
        RGGGLCYCRRRFCVCVGR
  • Function:Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002869    From 1 To 18 E-value: 0.0001 Score: 36.6
        RGGGLCYCRRRFCVCVGR
  • 2. L12A10434|    From 1 To 18 E-value: 0.0008 Score: 33.9
        RGGRLCYCRRRFCVCVGR
  • 3. L01A002867    From 1 To 18 E-value: 0.0008 Score: 33.9
        RGGRLCYCRRRFCVCVGR
  • 4. L01A002668    From 1 To 18 E-value: 0.003 Score: 32
        RGGRLCYCRPRFCVCVGR
  • 5. L03A000324    From 1 To 18 E-value: 0.003 Score: 31.6
        RGGRLCYCRPRFCVCVGR

Structure

  •   Domains
  •   1  Name:Cathelicidin    Interpro Link:IPR001894
  •   2  Name:Cathelicidin_CS    Interpro Link:IPR018216
  •   Structures
  •   1
    PDB:1KWI
    Method:X-ray
    Chains:A=30-130
  •   2
    PDB:1LXE
    Method:X-ray
    Chains:A=30-130
  •   3
    PDB:1PFP
    Method:X-ray
    Chains:A=30-130

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Aleshina G.M.,Shevchenko A.A.,Panyutich E.A.,Harwig S.S.L.,Kokryakov V.N.,
  •   Title:Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.
  •   Journal:FEBS Lett., 1993, 327, 231-236  [MEDLINE:93327946]
  •   [2]  Lehrer R.I.,Liu L.,Zhao C.,
  •   Title:Identification of a new member of the protegrin family by cDNA cloning.
  •   Journal:FEBS Lett., 1994, 346, 285-288  [MEDLINE:94283613]
  •   [3]  Lehrer R.I.,Ganz T.,Zhao C.,
  •   Title:The structure of porcine protegrin genes.
  •   Journal:FEBS Lett., 1995, 368, 197-202  [MEDLINE:95354835]
  •   [4]  Dumas C.,Aumelas A.,Strub M.-P.,Hoh F.,Sanchez J.F.,
  •   Title:Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein.
  •   Journal:Structure, 2002, 10, 1363-1370  [PubMed:12377122]
  •   [5]  Bock A.,Strub J.-M.,Sanchez J.F.,Hoh F.,Strub M.-P.,
  •   Title:Selenomethionine and selenocysteine double labeling strategy for crystallographic phasing.
  •   Journal:Structure, 2003, 11, 1359-1367  [PubMed:14604526]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: