Record in detail
General Info
- lamp_id:L01A002923
- Name:CECA_DROME
- FullName:Cecropin-A1/A2
- Source:Drosophila melanogaster
- Mass:4213.8 Da
- Sequence Length:40 aa
- Isoelectric Point:11.72
- Activity:Antibacterial
- Sequence
GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATARG - Function:Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ886
- 2 Database:DBAASP 5153
- 3 Database:dbAMP dbAMP_04370
- 4 Database:SATPdb satpdb21100
- 5 Database:Uniprot P14954
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000228 From 24 To 63 E-value: 8e-18 Score: 80.9
GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATARG - 2. L03A000209 From 24 To 63 E-value: 8e-18 Score: 80.9
GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATARG - 3. L12A08769| From 24 To 63 E-value: 8e-18 Score: 80.5
GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATARG - 4. L12A08777| From 24 To 63 E-value: 2e-17 Score: 79.3
GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATAKG - 5. L01A002923 From 1 To 40 E-value: 3e-17 Score: 79
GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATARG
Activity
- Antibacterial Activities
- 1 Target: Escherichia coli D21 MIC: 1.26 μg/ml (0.299018 μM)
- 2 Target: Enterobacter cloacae b12 MIC: 1.69 μg/ml (0.401063 μM)
- 3 Target: Pseudomonas aeruginosa OT97 MIC: 9.27 μg/ml (2.19991 μM)
- 4 Target: Serratia marcescens Dbl 1 MIC: 391.88 μg/ml (92.9992 μM)
- 5 Target: Bacillus megatherium Bm11 MIC: 10.96 μg/ml (2.60098 μM)
- 6 Target: Bacillus subtilis Bsll MIC: 67.42 μg/ml (15.9998 μM)
- 7 Target: Micrococcus luteus MI11 MIC: 35.82 μg/ml (8.50064 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Hultmark D.,Samakovlis C.,Kylsten P.,
- Title:The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.
- Journal:EMBO J., 1990, 9, 217-224 [MEDLINE:90107946]
- [2] Hultmark D.,Engstrom A.,Kylsten P.,Kimbrell D.A.,Samakovlis C.,
- Title:The immune response in Drosophila: pattern of cecropin expression and biological activity.
- Journal:EMBO J., 1990, 9, 2969-2976 [MEDLINE:90361012]
- [3] Wang L.,Clark A.G.,
- Title:Molecular population genetics of Drosophila immune system genes.
- Journal:Genetics, 1997, 147, 713-724 [MEDLINE:97476321]
- [4] Chigusa S.I.,Takahata N.,Satta Y.,Date A.,
- Title:Evolutionary history and mechanism of the Drosophila cecropin gene family.
- Journal:Immunogenetics, 1998, 47, 417-429 [MEDLINE:98221115]
- [5] Aguade M.,Ramos-Onsins S.,
- Title:Molecular evolution of the Cecropin multigene family in Drosophila: functional genes vs pseudogenes.
- Journal:Genetics, 1998, 150, 157-171 [MEDLINE:98393576]
- [6] Gocayne J.D.,Evans C.A.,Holt R.A.,Celniker S.E.,Adams M.D.,
- Title:The genome sequence of Drosophila melanogaster.
- Journal:Science, 2000, 287, 2185-2195 [MEDLINE:20196006]
- [7] Campbell K.S.,Matthews B.B.,Mungall C.J.,Crosby M.A.,Misra S.,
- Title:Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
- Journal:Genome Biol., 2002, 3, 0-0 [MEDLINE:22426069]
Comments
- Comments
No comments found on LAMP database