Record in detail
General Info
- lamp_id:L01A002925
- Name:CECB_DROME
- FullName:Cecropin-B
- Source:Drosophila melanogaster
- Mass:4226.9 Da
- Sequence Length:39 aa
- Isoelectric Point:12.1
- Activity:Antibacterial
- Sequence
GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR - Function:Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Cross-Linking
- Cross-linking
- 1 Database:APD 1563
- 2 Database:CAMP CAMPSQ887
- 3 Database:DBAASP 1856
- 4 Database:dbAMP dbAMP_04389
- 5 Database:DRAMP DRAMP03090
- 6 Database:SATPdb satpdb21058
- 7 Database:Uniprot P14956
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000201 From 24 To 62 E-value: 2e-17 Score: 79.3
GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR - 2. L12A08719| From 24 To 62 E-value: 2e-17 Score: 79.3
GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR - 3. L03A000200 From 24 To 62 E-value: 2e-17 Score: 79.3
GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR - 4. L03A000202 From 24 To 62 E-value: 2e-17 Score: 79.3
GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR - 5. L01A000546 From 2 To 40 E-value: 6e-17 Score: 77.8
GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR
Activity
- Antibacterial Activities
- 1 Target: Escherichia coli D21 MIC: 7.61 μg/ml (1.80037 μM)
- 2 Target: Enterobacter cloacae b12 MIC: 4.23 μg/ml (1.00073 μM)
- 3 Target: Pseudomonas aeruginosa OT97 MIC: 17.75 μg/ml (4.1993 μM)
- 4 Target: Bacillus megatherium Bm11 MIC: 15.64 μg/ml (3.70011 μM)
- 5 Target: Bacillus subtilis Bsll MIC: 13.53 μg/ml (3.20093 μM)
- 6 Target: Micrococcus luteus MI11 MIC: 249.39 μg/ml (59.0007 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Hultmark D.,Samakovlis C.,Kylsten P.,
- Title:The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.
- Journal:EMBO J., 1990, 9, 217-224 [MEDLINE:90107946]
- [2] Hultmark D.,Engstrom A.,Kylsten P.,Kimbrell D.A.,Samakovlis C.,
- Title:The immune response in Drosophila: pattern of cecropin expression and biological activity.
- Journal:EMBO J., 1990, 9, 2969-2976 [MEDLINE:90361012]
- [3] Wang L.,Clark A.G.,
- Title:Molecular population genetics of Drosophila immune system genes.
- Journal:Genetics, 1997, 147, 713-724 [MEDLINE:97476321]
- [4] Chigusa S.I.,Takahata N.,Satta Y.,Date A.,
- Title:Evolutionary history and mechanism of the Drosophila cecropin gene family.
- Journal:Immunogenetics, 1998, 47, 417-429 [MEDLINE:98221115]
- [5] Aguade M.,Ramos-Onsins S.,
- Title:Molecular evolution of the Cecropin multigene family in Drosophila: functional genes vs pseudogenes.
- Journal:Genetics, 1998, 150, 157-171 [MEDLINE:98393576]
- [6] Gocayne J.D.,Evans C.A.,Holt R.A.,Celniker S.E.,Adams M.D.,
- Title:The genome sequence of Drosophila melanogaster.
- Journal:Science, 2000, 287, 2185-2195 [MEDLINE:20196006]
- [7] Campbell K.S.,Matthews B.B.,Mungall C.J.,Crosby M.A.,Misra S.,
- Title:Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
- Journal:Genome Biol., 2002, 3, 0-0 [MEDLINE:22426069]
Comments
- Comments
No comments found on LAMP database