Record in detail


General Info

  • lamp_id:L01A002953
  • Name:NKL_PIG
  • FullName:Antimicrobial peptide NK-lysin
  • Source:Sus scrofa
  • Mass:8834.6 Da
  • Sequence Length:78 aa
  • Isoelectric Point:9.91
  • Activity:Antibacterial
  • Sequence
        GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE
  • Function:May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A002953    From 1 To 78 E-value: 4.00001e-40 Score: 154
        GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE
  • 2. L01A003154    From 1 To 77 E-value: 2e-39 Score: 152
        LICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE
  • 3. L12A03456|    From 1 To 78 E-value: 4e-38 Score: 148
        GLICESCRKIIQKLEDMVGPQPNEDTVTQAASQVCDKLKILRGLCKKIMRSFLRRISWDILTGKKPQAICVDIKICKE
  • 4. L02A000429    From 1 To 78 E-value: 4e-38 Score: 147
        GLICESCRKIIQKLEDMVGPQPNEDTVTQAASQVCDKLKILRGLCKKIMRSFLRRISWDILTGKKPQAICVDIKICKE
  • 5. L03A000055    From 1 To 78 E-value: 3e-37 Score: 145
        GYFCESCRKIIQKLEDMVGPQPNEDTVTQAASQVCDKLKILRGLCKKIMRSFLRRISWDILTGKKPQAICVDIKICKE

Structure

  •   Domains
  •   1  Name:SapB_1    Interpro Link:IPR007856
  •   2  Name:SapB_2    Interpro Link:IPR008138
  •   3  Name:Saposin-like    Interpro Link:IPR011001
  •   4  Name:SaposinB    Interpro Link:IPR008139
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli D21  MIC:  4.42 μg/ml  (0.500306 μM)  
  •   2  Target:  E. coli Bd2221/75  MIC:  88.35 μg/ml  (10.0005 μM)  
  •   3  Target:  P. aeruginosa  MIC:  1678.57 μg/ml  (190 μM)  
  •   4  Target:  Acinetobacter calcoaceticus  MIC:  61.84 μg/ml  (6.99975 μM)  
  •   5  Target:  Bacillus megaterium Bmll  MIC:  14.14 μg/ml  (1.60053 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Bergman T.,Boman A.,Agerberth B.,Gunne H.,Andersson M.,
  •   Title:NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.
  •   Journal:EMBO J., 1995, 14, 1615-1625  [MEDLINE:95255219]
  •   [2]  Otting G.,Ruysschaert J.-M.,Andersson M.,Liepinsh E.,
  •   Title:Saposin fold revealed by the NMR structure of NK-lysin.
  •   Journal:Nat. Struct. Biol., 1997, 4, 793-795  [MEDLINE:97475218]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: