Record in detail


General Info

  • lamp_id:L01A002957
  • Name:PFPB_ENTHI
  • FullName:Pore-forming peptide ameobapore B
  • Source:Entamoeba histolytica
  • Mass:8301.7 Da
  • Sequence Length:77 aa
  • Isoelectric Point:4.96
  • Activity:Antibacterial
  • Sequence
        GAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC
  • Function:Forms pores in the cytoplasmic membrane of host cells. Has antibacterial activity against M.luteus, no activity against E.coli. Implicated in the cytolytic activity of the parasite.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000239    From 20 To 96 E-value: 2e-40 Score: 156
        GAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC
  • 2. L01A002957    From 1 To 77 E-value: 8e-40 Score: 153
        GAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC
  • 3. L03A000240    From 20 To 96 E-value: 1e-37 Score: 146
        GSILCNLCKDTVNLIENLLTVDGAQAVRQYIDNLCAKADGFLGTLCNKILSFGVDELVKLIENHVDPVVICEKIHAC
  • 4. L13A013594    From 1 To 50 E-value: 9e-24 Score: 100
        GAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKIL
  • 5. L03A000126    From 21 To 97 E-value: 5e-23 Score: 98.2
        GPIVCNLCTGLINTLENLLTTKGADKVKDYIDSLCNKASGFIATLCTKVLDFGVDKLIQLIEDKVDANAICAKIHAC

Structure

  •   Domains
  •   1  Name:SapB_1    Interpro Link:IPR007856
  •   2  Name:SapB_2    Interpro Link:IPR008138
  •   3  Name:Saposin-like    Interpro Link:IPR011001
  •   4  Name:SaposinB    Interpro Link:IPR008139
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Mueller-Eberhard H.J.,Tannich E.,Nickel R.,Andrae J.,Leippe M.,
  •   Title:Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes.
  •   Journal:Mol. Microbiol., 1994, 14, 895-904  [MEDLINE:95231296]

Comments

  •   Comments

    •     No comments found on LAMP database



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