Record in detail


General Info

  • lamp_id:L01A002962
  • Name:STMX_STOCA
  • FullName:Stomoxyn
  • Source:Stomoxys calcitrans
  • Mass:4416.1 Da
  • Sequence Length:42 aa
  • Isoelectric Point:11.42
  • Activity:Antibacterial
  • Sequence
        RGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAAT
  • Function:Has antimicrobial activity against most Gram-positive and Gram-negative bacteria, filamentous fungi and yeasts tested. Has trypanolytic effect on T.b.rhodesiense and limited hemolytic activity against bovine red blood cells.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000227    From 25 To 66 E-value: 2e-18 Score: 83.2
        RGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAAT
  • 2. L01A002962    From 1 To 42 E-value: 5e-18 Score: 81.3
        RGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAAT
  • 3. L13A022946    From 1 To 33 E-value: 0.0000000000001 Score: 67
        RGFRKHFNKLVKKVKHTISETAHVAKDTAVIAG
  • 4. L13A011665    From 1 To 33 E-value: 0.0000000000001 Score: 67
        RGFRKHFNKLVKKVKHTISETAHVAKDTAVIAG
  • 5. L11A011812    From 1 To 40 E-value: 0.000000000002 Score: 62.4
        GFRKRFNKLVKKVKHTIKETANVSKDVAIVAGSGVAVGAA

Structure

  •   Domains
  •   1  Name:Stomoxyn    Interpro Link:IPR021037
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli K12 RM148  MIC:  0.84 μg/ml  (0.190213 μM)  
  •   2  Target:  E. coli D22  MIC:  0.84 μg/ml  (0.190213 μM)  
  •   3  Target:  E. coli D31  MIC:  0.84 μg/ml  (0.190213 μM)  
  •   4  Target:  E. coli SBS363  MIC:  0.84 μg/ml  (0.190213 μM)  
  •   5  Target:  E. coli 1106  MIC:  0.84 μg/ml  (0.190213 μM)  
  •   6  Target:  Enterobacter cloacae b12  MIC:  13.78 μg/ml  (3.1204 μM)  
  •   7  Target:  Erwinia carotovora  MIC:  3.44 μg/ml  (0.778968 μM)  
  •   8  Target:  Klebsiella pneumoniae  MIC:  3.44 μg/ml  (0.778968 μM)  
  •   9  Target:  Pseudomonas aeruginosa  MIC:  1.72 μg/ml  (0.389484 μM)  
  •   10  Target:  Salmonella typhimurium  MIC:  1.72 μg/ml  (0.389484 μM)  
  •   11  Target:  Xanthomonas campestris  MIC:  1.72 μg/ml  (0.389484 μM)  
  •   12  Target:  Aerococcus viridans  MIC:  3.44 μg/ml  (0.778968 μM)  
  •   13  Target:  Bacillus megaterium  MIC:  3.44 μg/ml  (0.778968 μM)  
  •   14  Target:  B. subtilis  MIC:  27.6 μg/ml  (6.24986 μM)  
  •   15  Target:  Enterococcus faecalis  MIC:  3.44 μg/ml  (0.778968 μM)  
  •   16  Target:  M. luteus  MIC:  3.44 μg/ml  (0.778968 μM)  
  •   17  Target:  Streptococcus pyogenes  MIC:  6.89 μg/ml  (1.5602 μM)  
  •   18  Target:  A. fumigatus  MIC:  220.81 μg/ml  (50.0011 μM)  
  •   19  Target:  Fusarium culmorum  MIC:  1.72 μg/ml  (0.389484 μM)  
  •   20  Target:  Fusarium oxysporum  MIC:  3.44 μg/ml  (0.778968 μM)  
  •   21  Target:  Nectria haematococca  MIC:  1.72 μg/ml  (0.389484 μM)  
  •   22  Target:  N. crassa  MIC:  13.78 μg/ml  (3.1204 μM)  
  •   23  Target:  Trichoderma viride  MIC:  6.89 μg/ml  (1.5602 μM)  
  •   24  Target:  Trichophyton mentagrophytes  MIC:  13.78 μg/ml  (3.1204 μM)  
  •   25  Target:  C. albicans  MIC:  110.4 μg/ml  (24.9994 μM)  
  •   26  Target:  Candida glabrata  MIC:  110.4 μg/ml  (24.9994 μM)  
  •   27  Target:  C. neoformans  MIC:  3.44 μg/ml  (0.778968 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Brun R.,Vovelle F.,Hamilton J.V.,Munks R.J.L.,Boulanger N.,
  •   Title:Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans.
  •   Journal:J. Biol. Chem., 2002, 277, 49921-49926  [PubMed:12372834]
  •   [2]  Vovelle F.,Bulet P.,Boulanger N.,Meudal H.,Landon C.,
  •   Title:Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation.
  •   Journal:Biopolymers, 2006, 81, 92-103  [PubMed:16170803]

Comments

  •   Comments

    •     No comments found on LAMP database



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