Record in detail

lamp_id:L01A002993
Name:TACHC_TACTR
FullName:Tachystatin-C
Source:Tachypleus tridentatus
Mass:4921.6 Da
Sequence Length:41 aa
Isoelectric Point:9.55
Activity:Antibacterial, Antifungal
Sequence
DYDWSLRGPPKCATYGQKCRTWSPPNCCWNLRCKAFRCRPR
Function:Binds to chitin. Shows strong activity against E.coli (IC(50) is 1.2 ug/ml). Is also very active against S.aureus (IC(50) is 0.8 ug/ml), C.albicans (IC(50) is 0.9 ug/ml) and P.pastoris (IC(50) is 0.3 ug/ml). Binds to chitin (5.2 uM are required to obtain 50% of binding). Causes hemolysis on sheep erythrocytes, probably by forming ion-permeable pores.

Top similar AMPs on LAMP
1. L01A002993 From 1 To 41 E-value: 2e-19 Score: 85.9
DYDWSLRGPPKCATYGQKCRTWSPPNCCWNLRCKAFRCRPR
2. L02A001009 From 1 To 41 E-value: 1e-18 Score: 83.2
DYDWSLRGPPKCATYGQKCRTWSPRNCCWNLRCKAFRCRPR
3. L01A002991 From 3 To 26 E-value: 3.1 Score: 22.3
SCLFRGARCRVYSGRSCCFGYYCR
4. L01A003326 From 4 To 26 E-value: 3.4 Score: 22.3
CLFRGARCRVYSGRSCCFGYYCR
5. L12A10090| From 13 To 29 E-value: 5.6 Score: 21.6
GQQLRNISPPQRCPSLR

Antibacterial Activities
1 Target: E. coli IC50: 1.2 μg/ml (0.243823 μM)
2 Target: S. aureus IC50: 0.8 μg/ml (0.162549 μM)
3 Target: C. albicans IC50: 0.9 μg/ml (0.182867 μM)
4 Target: P. pastoris IC50: 0.3 μg/ml (0.0609558 μM)

Reference
[1] Iwanaga S.,Hirata M.,Nagayama R.,Omotezako M.,Osaki T.,
Title:Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins.
Journal:J. Biol. Chem., 1999, 274, 26172-26178 [MEDLINE:99403058]