Record in detail
General Info
- lamp_id:L01A003029
- Name:DEF6_RABIT
- FullName:Neutrophil antibiotic peptide NP-5
- Source:Oryctolagus cuniculus
- Mass:3551.1 Da
- Sequence Length:33 aa
- Isoelectric Point:8.64
- Activity:Antimicrobial
- Sequence
VFCTCRGFLCGSGERASGSCTINGVRHTLCCRR - Function:Microbicidal activity.
Cross-Linking
- Cross-linking
- 1 Database:APD 314
- 2 Database:CAMP CAMPSQ1619
- 3 Database:dbAMP dbAMP_11712
- 4 Database:DRAMP DRAMP03800
- 5 Database:SATPdb satpdb26820
- 6 Database:Uniprot P07466
- 7 Database:DEF DEF254
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000280 From 63 To 95 E-value: 0.000000000000006 Score: 71.2
VFCTCRGFLCGSGERASGSCTINGVRHTLCCRR - 2. L01A003029 From 1 To 33 E-value: 0.0000000000002 Score: 65.9
VFCTCRGFLCGSGERASGSCTINGVRHTLCCRR - 3. L03A000281 From 63 To 95 E-value: 0.00000000004 Score: 58.5
VSCTCRRFSCGFGERASGSCTVNGVRHTLCCRR - 4. L01A003030 From 1 To 33 E-value: 0.0000000005 Score: 54.7
VSCTCRRFSCGFGERASGSCTVNGVRHTLCCRR - 5. L12A09221| From 63 To 94 E-value: 0.00002 Score: 39.3
IICHCRRLLCLSSEHLSGICTIKGVRYPFCCR
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Lehrer R.I.,Harwig S.S.L.,Delange R.J.,Brown D.M.,Selsted M.E.,
- Title:Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.
- Journal:J. Biol. Chem., 1985, 260, 4579-4584 [MEDLINE:85182561]
- [2] Bassolino D.A.,Morrison R.D.,Selsted M.E.,Hare D.R.,Pardi A.,
- Title:Solution structures of the rabbit neutrophil defensin NP-5.
- Journal:J. Mol. Biol., 1988, 201, 625-636 [MEDLINE:88332997]
- [3] Pardi A.,Kitchen D.B.,Bassolino D.A.,Levy R.M.,
- Title:Solution structures of proteins from NMR data and modeling: alternative folds for neutrophil peptide 5.
- Journal:Biochemistry, 1989, 28, 9361-9372 [MEDLINE:90122800]
- [4] Pardi A.,Levy R.M.,Bassolino D.A.,Kominos D.,
- Title:Analysis of side-chain conformational distributions in neutrophil peptide-5 NMR structures.
- Journal:Biopolymers, 1990, 29, 1807-1822 [MEDLINE:91002855]
- [5] Ganz T.,Rayner J.R.,Couto M.,Michaelson D.,
- Title:Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?
- Journal:J. Leukoc. Biol., 1992, 51, 634-639 [MEDLINE:92308748]
- [6] Palfree R.G.E.,Solomon S.,Tremblay A.,Sadro L.C.,
- Title:Differential expression of corticostatins/defensins: higher levels of CS-4 (NP-2) transcripts compared with CS-6 (NP-5) in rabbit lung.
- Journal:Biochem. Biophys. Res. Commun., 1993, 190, 1009-1016 [MEDLINE:93176141]
Comments
- Comments
No comments found on LAMP database