Record in detail


General Info

  • lamp_id:L01A003040
  • Name:DEF4_PANTR
  • FullName:Neutrophil defensin 4
  • Source:Pan troglodytes
  • Mass:3830.5 Da
  • Sequence Length:34 aa
  • Isoelectric Point:8.38
  • Activity:Antimicrobial
  • Sequence
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
  • Function:Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A09030|    From 64 To 97 E-value: 0.000000000000003 Score: 72
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
  • 2. L01A000836    From 64 To 97 E-value: 0.000000000000004 Score: 72
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
  • 3. L01A003040    From 1 To 34 E-value: 0.00000000000007 Score: 67.8
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD
  • 4. L01A000427    From 1 To 33 E-value: 0.0000000000004 Score: 65.1
        VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
  • 5. L12A08994|    From 67 To 97 E-value: 0.01 Score: 30.8
        TCYCRSSFCKFGELPSGTCTLNGIRYRFCCS

Structure

  •   Domains
  •   1  Name:Alpha-defensin    Interpro Link:IPR016327
  •   2  Name:Defensin_beta/neutrophil    Interpro Link:IPR006080
  •   3  Name:Defensin_propep    Interpro Link:IPR002366
  •   4  Name:Mammalian_defensins    Interpro Link:IPR006081
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Zhang G.,Hughes A.L.,Patil A.,
  •   Title:Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.
  •   Journal:Physiol. Genomics, 2004, 20, 1-11  [PubMed:15494476]

Comments

  •   Comments

    •     No comments found on LAMP database



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