Record in detail
General Info
- lamp_id:L01A003083
- Name:CYO12_VIOAR
- FullName:Varv peptide E
- Source:Viola arvensis
- Mass:2916.3 Da
- Sequence Length:29 aa
- Isoelectric Point:5.93
- Activity:Antimicrobial, ,Anticancer
- Sequence
GLPICGETCVGGTCNTPGCSCSWPVCTRN - Function:Probably participates in a plant defense mechanism. Has cytotoxic activity against human lymphoma U-937 GTB and human myeloma RPMI-8226/s cell lines.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ6434
- 2 Database:DBAASP 2451
- 3 Database:dbAMP dbAMP_03708
- 4 Database:DRAMP DRAMP00788
- 5 Database:SATPdb satpdb24600
- 6 Database:Uniprot P83835
- 7 Database:PHY PHYT00214
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A003083 From 1 To 29 E-value: 0.00000000003 Score: 58.9
GLPICGETCVGGTCNTPGCSCSWPVCTRN - 2. L01A003082 From 1 To 29 E-value: 0.00000000004 Score: 58.2
GLPVCGETCVGGTCNTPGCSCSWPVCTRN - 3. L06AT00213 From 1 To 29 E-value: 0.00000000006 Score: 58.2
GLPICGETCVGGSCNTPGCSCSWPVCTRN - 4. L02A001074 From 1 To 29 E-value: 0.00000000006 Score: 57.8
GLPICGETCVGGTCNTPGCTCSWPVCTRN - 5. L06AT00212 From 1 To 29 E-value: 0.00000000007 Score: 57.8
GVPICGETCVGGTCNTPGCSCSWPVCTRN
Activity
- Antibacterial Activities
- 1 Target: RPMI-8226/s myeloma IC50: 11.67 μg/ml (4.00165 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Claeson P.,Bohlin L.,Johansson S.,Luijendijk T.,Goeransson U.,
- Title:Seven novel macrocyclic polypeptides from Viola arvensis.
- Journal:J. Nat. Prod., 1999, 62, 283-286 [MEDLINE:99177275]
- [2] Larsson R.,Gullbo J.,Hocaoglu Z.,Goransson U.,Svangard E.,
- Title:Cytotoxic cyclotides from Viola tricolor.
- Journal:J. Nat. Prod., 2004, 67, 144-147 [PubMed:14987049]
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