Record in detail


General Info

  • lamp_id:L01A003083
  • Name:CYO12_VIOAR
  • FullName:Varv peptide E
  • Source:Viola arvensis
  • Mass:2916.3 Da
  • Sequence Length:29 aa
  • Isoelectric Point:5.93
  • Activity:Antimicrobial, ,Anticancer
  • Sequence
        GLPICGETCVGGTCNTPGCSCSWPVCTRN
  • Function:Probably participates in a plant defense mechanism. Has cytotoxic activity against human lymphoma U-937 GTB and human myeloma RPMI-8226/s cell lines.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003083    From 1 To 29 E-value: 0.00000000003 Score: 58.9
        GLPICGETCVGGTCNTPGCSCSWPVCTRN
  • 2. L01A003082    From 1 To 29 E-value: 0.00000000004 Score: 58.2
        GLPVCGETCVGGTCNTPGCSCSWPVCTRN
  • 3. L06AT00213    From 1 To 29 E-value: 0.00000000006 Score: 58.2
        GLPICGETCVGGSCNTPGCSCSWPVCTRN
  • 4. L02A001074    From 1 To 29 E-value: 0.00000000006 Score: 57.8
        GLPICGETCVGGTCNTPGCTCSWPVCTRN
  • 5. L06AT00212    From 1 To 29 E-value: 0.00000000007 Score: 57.8
        GVPICGETCVGGTCNTPGCSCSWPVCTRN

Structure

  •   Domains
  •   1  Name:Cyclotide    Interpro Link:IPR005535
  •   2  Name:Cyclotide_moebius_CS    Interpro Link:IPR012324
  •   3  Name:Cyclotide_subgr    Interpro Link:IPR017307
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  RPMI-8226/s myeloma  IC50:  11.67 μg/ml  (4.00165 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Claeson P.,Bohlin L.,Johansson S.,Luijendijk T.,Goeransson U.,
  •   Title:Seven novel macrocyclic polypeptides from Viola arvensis.
  •   Journal:J. Nat. Prod., 1999, 62, 283-286  [MEDLINE:99177275]
  •   [2]  Larsson R.,Gullbo J.,Hocaoglu Z.,Goransson U.,Svangard E.,
  •   Title:Cytotoxic cyclotides from Viola tricolor.
  •   Journal:J. Nat. Prod., 2004, 67, 144-147  [PubMed:14987049]

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